Citrulline vs Propranolol for heart & lipids
Short answer: For heart & lipids, users rate them about the same: 100% report improvement with Citrulline (14 reports) and 100% with Propranolol (12 reports).
Citrulline has 51 meta-analyses and 258 randomized trials on PubMed; Propranolol has 268 and 1,961.
Based on 157 reports about Citrulline and 166 about Propranolol. Not medical advice.
| Citrulline Supplement | Propranolol Medication | |
|---|---|---|
| Users say it helped | 84%helped58 reports · medium confidence | 79%helped105 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 51 / 258 | 268 / 1,961 |
| Mainly used for | ||
| Anxiety % reporting improvement | — | 94% (101) |
| Performance % reporting improvement | 100% (31) | 100% (2) |
| Heart & lipids % reporting improvement | 100% (14) | 100% (12) |
| Libido % reporting improvement | 90% (20) | — |
| Sleep % reporting improvement | — | 40% (5) |
| Common side effects | erectile dysfunction, tooth erosion, tooth enamel, gerd | insomnia, depression, fatigue, weight gain |
| Typical dose reported | 1 g | Not listed |
Supplementation of some but not all micronutrients may benefit cardiometabolic health. This study highlights the importance of micronutrient diversity and the balance of benefits and risks to promote and maintain cardiovascular health in diverse populations. (Antioxidant Supplementation in the Prevention and Treatment of Cardiovascular Diseases; CRD42022315165).
J Am Coll Cardiol, 2022 ↗“try all the standard vasodilators - citrulline and agmatine helped me a lot.”
In this systematic review and network meta-analysis, mirtazapine, biperiden, and vitamin B6 were associated with the greatest efficacy for AIA, with vitamin B6 having the best efficacy and tolerance profile. Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.
JAMA Netw Open, 2024 ↗“I just got a script for propranolol that I can take as needed and it's been a game changer.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate