Lithium Orotate vs Propranolol for anxiety
Short answer: For anxiety, users rate them about the same: 98% report improvement with Lithium Orotate (80 reports) and 94% with Propranolol (101 reports).
Lithium Orotate has 581 meta-analyses and 979 randomized trials on PubMed; Propranolol has 268 and 1,961.
Based on 307 reports about Lithium Orotate and 166 about Propranolol. Not medical advice.
| Lithium Orotate Supplement | Propranolol Medication | |
|---|---|---|
| Users say it helped | 76%helped138 reports · high confidence | 79%helped105 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 581 / 979 | 268 / 1,961 |
| Mainly used for | ||
| Anxiety % reporting improvement | 98% (80) | 94% (101) |
| Mood % reporting improvement | 92% (108) | 20% (5) |
| Sleep % reporting improvement | 100% (16) | 40% (5) |
| Focus % reporting improvement | 81% (16) | 100% (4) |
| Heart & lipids % reporting improvement | — | 100% (12) |
| Common side effects | brain fog, emotional blunting, sexual dysfunction, drowsiness | insomnia, depression, fatigue, weight gain |
| Typical dose reported | 1-2 tablets | Not listed |
Although it is yet to be determined which is more effective between lithium or lecanemab or donanemab, lithium may be more effective than aducanumab. Aducanumab, lecanemab and donanemab do not appear to differ in their effectiveness on cognitive function. Low-dose lithium may be safer than aducanumab, lecanemab and donanemab.
Ageing Res Rev, 2024 ↗“The lithium is absolutely curbing my mania... My social anxiety is 100% gone when I take lithium orotate.”
In this systematic review and network meta-analysis, mirtazapine, biperiden, and vitamin B6 were associated with the greatest efficacy for AIA, with vitamin B6 having the best efficacy and tolerance profile. Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.
JAMA Netw Open, 2024 ↗“I just got a script for propranolol that I can take as needed and it's been a game changer.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate