Citrulline vs Tadalafil for performance
Short answer: For performance, users rate them about the same: 100% report improvement with Citrulline (31 reports) and 97% with Tadalafil (69 reports).
Citrulline has 51 meta-analyses and 258 randomized trials on PubMed; Tadalafil has 120 and 347.
Based on 157 reports about Citrulline and 253 about Tadalafil. Not medical advice.
| Citrulline Supplement | Tadalafil Medication | |
|---|---|---|
| Users say it helped | 84%helped58 reports · medium confidence | 77%helped142 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 51 / 258 | 120 / 347 |
| Mainly used for | ||
| Libido % reporting improvement | 90% (20) | 91% (99) |
| Performance % reporting improvement | 100% (31) | 97% (69) |
| Heart & lipids % reporting improvement | 100% (14) | 95% (22) |
| Focus % reporting improvement | — | 90% (10) |
| Energy % reporting improvement | 75% (4) | 100% (6) |
| Common side effects | erectile dysfunction, tooth erosion, tooth enamel, gerd | headache, stuffy nose, heartburn, lower back |
| Typical dose reported | 1 g | Not listed |
Supplementation of some but not all micronutrients may benefit cardiometabolic health. This study highlights the importance of micronutrient diversity and the balance of benefits and risks to promote and maintain cardiovascular health in diverse populations. (Antioxidant Supplementation in the Prevention and Treatment of Cardiovascular Diseases; CRD42022315165).
J Am Coll Cardiol, 2022 ↗“try all the standard vasodilators - citrulline and agmatine helped me a lot.”
Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients' sexual confidence. Furthermore, patients and their partners prefer tadalafil to sildenafil. Hence, tadalafil may be a better choice for ED treatment.
Int Urol Nephrol, 2017 ↗“After a week of 2.5 mg twice a day, this is my favourite drug ever. My brain fog has gone...My mood is so much better, similar to an SSRI but without the flat feeling.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate