Berberine vs MK-677 for appetite
Short answer: For appetite, more users report improvement with Berberine — 87% of 15 reports, versus 62% of 152 for MK-677.
Berberine has 109 meta-analyses and 110 randomized trials on PubMed; MK-677 has 0 and 15.
Based on 294 reports about Berberine and 692 about MK-677. Not medical advice.
| Berberine Supplement | MK-677 Substance | |
|---|---|---|
| User score | 47 | 45 |
| Verdict | Mixed | Mixed |
| Positive of reports that state an outcome | 56% | 41% |
| Reports | 294 | 692 |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 109 / 110 | 0 / 15 |
| Mainly used for | ||
| Weight loss % reporting improvement | 84% (19) | 63% (43) |
| Appetite % reporting improvement | 87% (15) | 62% (152) |
| Focus % reporting improvement | 33% (6) | 0% (3) |
| Energy % reporting improvement | 90% (21) | 39% (49) |
| Sleep % reporting improvement | 75% (4) | 78% (123) |
| Anxiety % reporting improvement | 50% (8) | 5% (21) |
| Mood % reporting improvement | 86% (14) | 59% (17) |
| Performance % reporting improvement | 67% (3) | 88% (68) |
| Recovery % reporting improvement | — | 99% (81) |
| Pain & inflammation % reporting improvement | 100% (4) | 67% (18) |
| Digestion % reporting improvement | 60% (15) | 50% (2) |
| Libido % reporting improvement | — | 25% (8) |
| Hormones % reporting improvement | 67% (3) | 41% (34) |
| Blood sugar % reporting improvement | 86% (58) | 5% (44) |
| Heart & lipids % reporting improvement | 92% (13) | 8% (12) |
| Skin & hair % reporting improvement | — | 92% (24) |
| Longevity % reporting improvement | 50% (2) | — |
| Common side effects | stomach issues, fatigue, constipation, anxiety | water retention, fatigue, hunger, stomach issues |
| Typical dose reported | 400-500 mg / daily | 12.5 mg / before dinner |
BerberineFull Berberine profile →
Latest review conclusion
Treatment with berberine may be safe since it does not increase the incidence of total adverse events and the risk of hypoglycemia. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=292975, identifier CRD42021292975.
Front Pharmacol, 2022 ↗What a user said
“I started berberine and inositol, and began having energy that I did not have before. Somehow, my recovery after working out wasn't as long either.”
MK-677Full MK-677 profile →
What a user said
“From my own experience (also have suffered from poor sleep), i experienced a noticeable increase in sleep quality even with a low dose.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate