MK-677 vs NAC for appetite
Short answer: For appetite, more users report improvement with NAC — 90% of 31 reports, versus 62% of 152 for MK-677.
MK-677 has 0 meta-analyses and 15 randomized trials on PubMed; NAC has 387 and 767.
Based on 692 reports about MK-677 and 1,645 about NAC. Not medical advice.
| MK-677 Substance | NAC Supplement | |
|---|---|---|
| User score | 45 | 49 |
| Verdict | Mixed | Mixed |
| Positive of reports that state an outcome | 41% | 55% |
| Reports | 692 | 1,645 |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 0 / 15 | 387 / 767 |
| Mainly used for | ||
| Weight loss % reporting improvement | 63% (43) | 75% (4) |
| Appetite % reporting improvement | 62% (152) | 90% (31) |
| Focus % reporting improvement | 0% (3) | 82% (156) |
| Energy % reporting improvement | 39% (49) | 74% (78) |
| Sleep % reporting improvement | 78% (123) | 71% (41) |
| Anxiety % reporting improvement | 5% (21) | 90% (259) |
| Mood % reporting improvement | 59% (17) | 65% (274) |
| Memory % reporting improvement | — | 79% (14) |
| Performance % reporting improvement | 88% (68) | 75% (8) |
| Recovery % reporting improvement | 99% (81) | 86% (14) |
| Pain & inflammation % reporting improvement | 67% (18) | 86% (28) |
| Digestion % reporting improvement | 50% (2) | 72% (18) |
| Libido % reporting improvement | 25% (8) | 29% (7) |
| Hormones % reporting improvement | 41% (34) | 88% (8) |
| Blood sugar % reporting improvement | 5% (44) | 100% (3) |
| Heart & lipids % reporting improvement | 8% (12) | 67% (12) |
| Skin & hair % reporting improvement | 92% (24) | 89% (18) |
| Immunity % reporting improvement | — | 97% (34) |
| Longevity % reporting improvement | — | 100% (7) |
| Common side effects | water retention, fatigue, hunger, stomach issues | anhedonia, fatigue, stomach issues, depression |
| Typical dose reported | 12.5 mg / before dinner | as needed |
“From my own experience (also have suffered from poor sleep), i experienced a noticeable increase in sleep quality even with a low dose.”
Taken together, these preliminary findings suggest that dietetic approaches might be included as part of BD treatment. Also considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.
Nutr Neurosci, 2023 ↗“NAC has helped me stay calm and reduce anxiety as well as gives me loads of energy if I am sleep deprived.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate