Creatine vs MK-677 for performance
Short answer: For performance, more users report improvement with Creatine — 97% of 320 reports, versus 88% of 68 for MK-677.
Creatine has 763 meta-analyses and 2,794 randomized trials on PubMed; MK-677 has 0 and 15.
Based on 1,564 reports about Creatine and 692 about MK-677. Not medical advice.
| Creatine Supplement | MK-677 Substance | |
|---|---|---|
| User score | 53 | 45 |
| Verdict | Mostly positive | Mixed |
| Positive of reports that state an outcome | 67% | 41% |
| Reports | 1,564 | 692 |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 763 / 2,794 | 0 / 15 |
| Mainly used for | ||
| Weight loss % reporting improvement | 82% (11) | 63% (43) |
| Appetite % reporting improvement | 67% (3) | 62% (152) |
| Focus % reporting improvement | 92% (211) | 0% (3) |
| Energy % reporting improvement | 97% (205) | 39% (49) |
| Sleep % reporting improvement | 27% (73) | 78% (123) |
| Anxiety % reporting improvement | 62% (24) | 5% (21) |
| Mood % reporting improvement | 85% (103) | 59% (17) |
| Memory % reporting improvement | 91% (70) | — |
| Performance % reporting improvement | 97% (320) | 88% (68) |
| Recovery % reporting improvement | 98% (62) | 99% (81) |
| Pain & inflammation % reporting improvement | 50% (4) | 67% (18) |
| Digestion % reporting improvement | 0% (6) | 50% (2) |
| Libido % reporting improvement | 82% (11) | 25% (8) |
| Hormones % reporting improvement | 75% (12) | 41% (34) |
| Blood sugar % reporting improvement | 100% (3) | 5% (44) |
| Heart & lipids % reporting improvement | 67% (6) | 8% (12) |
| Skin & hair % reporting improvement | 17% (12) | 92% (24) |
| Longevity % reporting improvement | 100% (4) | — |
| Common side effects | hair loss, stomach issues, insomnia, water retention | water retention, fatigue, hunger, stomach issues |
| Typical dose reported | daily | 12.5 mg / before dinner |
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“I actually feel a lot better. Mentally clearer and more balanced, like I have my brain back.”
“From my own experience (also have suffered from poor sleep), i experienced a noticeable increase in sleep quality even with a low dose.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate