What people actually say
10,564 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
MetforminMixed
“Berberine has done zero for my pre diabetic glucose levels or weight. Metformin has and I changed nothing else.”Source discussion ↗
MetforminMixed
“2 days with Metformin and that’s gone. I feel like I did when i was in my 30’s.”Source discussion ↗
MetforminMixed
“Recently, he stopped because it was found to interfere with some other important function (muscle building?, I can't remember), so he stopped taking it. He said the benefits did not outweigh the costs.”Source discussion ↗
MetforminMixed
“Personally, I used metformin for 2 years, though I stopped for a multitude of reasons.”Source discussion ↗
MetforminMixed
“Terrible side effects for me stomach wise and didnt particularly impact my blood sugar either...A1c went from 5.9 to 5.6 on metformin.”Source discussion ↗
MetforminMixed
“Been on it for 17 years. Only recognizable benefit is to reduce my blood sugar. No side effects noted, dosage for 14 years has been 2,000 mg a day, split half in morning and half in evening.”Source discussion ↗
MetforminMixed
“I had brutal diarreah and stomach aches for weeks and then I stopped it. Can't handle it.”Source discussion ↗
MetforminMixed
“My doctor prescribed it for life extension purposes / increase insulin sensitivity. The main reason I stopped to was that it reduced exercise performance.”Source discussion ↗
MetforminMixed
“My ex used to take it (PCOS). It fucked her stomach up pretty badly so she stopped after a while.”Source discussion ↗
MetforminMixed
“Metformin: 500 mg nightly. Mainly for theoretical longevity benefits... I recently reduced the dose because I value exercise adaptation, recovery, and performance.”Source discussion ↗
MetforminMixed
“Metformin (2 months, hoping to reduce hunger or increase energy), and there is way many more and others I can't remember.”Source discussion ↗
MetforminMixed
“Metformin has a list of side effects whereas (for me) berberine has zero side effects.”Source discussion ↗
MetforminMixed
“I have never taken glp but was having similar nonsensical results and metformin fixed it instantly.”Source discussion ↗
MetforminMixed
“Recently I've had stomach issues return which can happen on metformin so I've stopped it for a few weeks”Source discussion ↗
MetforminMixed
“Uneasy stomach and loose stool for maybe 3-4 days but after that haven't noticed anything. I take 1g extended daily usually with a meal”Source discussion ↗
Magnesium OxideMostly negative
“The next day, my legs felt amazing. I could walk again without feeling like my legs were deadweight.”Source discussion ↗
Magnesium OxideMostly negative
“I've tried various forms of magnesium over the past year including threonate, glycinate, citrate, oxide, and taurate. They all give the same negative side effects.”Source discussion ↗
Magnesium OxideMostly negative
“I was taking crappy magnesium oxide supplements for years with basically no effect, besides diarrhea if I took too much magnesium oxide. Magnesium oxide has basically no bioavailability.”Source discussion ↗
Magnesium OxideMostly negative
“If it's oxide, which has 4-5% bioavailability, will probably do nothing for you like it does for me.”Source discussion ↗
Magnesium OxideMostly negative
“Oxide has shit bioavailability but that didn't bother unless I too ka fairly large dose, it's basically a diuretic.”Source discussion ↗
Magnesium OxideMostly negative
“I feel emotionally blunted when I take magnesium during the day, but it's great at night.”Source discussion ↗
Magnesium OxideMostly negative
“I'm taking 250mg of magnesium oxide twice daily to see if it could help with my depression/anxiety/fatigue combo. Well, it has.”Source discussion ↗
Magnesium OxideMostly negative
“I have tried magnesium oxide and citrate and react fine to both, but neither seem great for sleep.”Source discussion ↗
Magnesium OxideMostly negative
“I also taken Magnesium Oxide but it was horrible, messed up my bowel movement and it didn't have any effect on my sleep at all.”Source discussion ↗
Magnesium OxideMostly negative
“I had heart palpitations for 20 years and just recently started taking magnesium oxide about 4 months ago. Life changing.”Source discussion ↗
Magnesium OxideMostly negative
“I was previously taking magnesium oxide but that gave me runny shits on the daily, but I kept taking it because it completely stopped my migraines.”Source discussion ↗
Magnesium OxideMostly negative
“Magnesium Oxide kept me up all night! A friend told me to take it before bed for better absorption but it wired me.”Source discussion ↗
Magnesium OxideMostly negative
“The first night I took it I slept so deep and long it was like I was drugged...My mood lifts every time, I get more energy, negative intrusive thoughts go quiet”Source discussion ↗
Magnesium OxideMostly negative
“No magnesium helps for sleep. I tried magnesium citrate, magnesium oxide, magnesium glycinate”Source discussion ↗
Magnesium OxideMostly negative
“I've never had any negative side effects from it (ie gut distress, diarrhea etc), that only happens when you use Oxide and maybe Citrate”Source discussion ↗
Magnesium OxideMostly negative
“I tried magnesium oxide 500mg (first) which made me feel like ass”Source discussion ↗
ValerianMixed
“i find valarian helps me stay asleep, if you can get past the smell.”Source discussion ↗
ValerianMixed
“I then tried raising GABA instead, using Valerian, Passion Flower, L-Theanine etc. All at max dosage, no effect whatsoever.”Source discussion ↗
ValerianMixed
“For years I struggled with post workout insomnia. PS along with valerian helped.”Source discussion ↗
ValerianMixed
“Valerian/chamomile (also calm, but not as much, chamomile in particular seems to be amazing when im actually very stressed out but not much otherwise)”Source discussion ↗
ValerianMixed
“Negative effects on sleep quality came from valerian...valerian vastly improves my latency but quality drops significantly.”Source discussion ↗
ValerianMixed
“kava, CBD, and valerian feel the most mentally soothing to me without also making me okay with neglecting my life like SSRIs did.”Source discussion ↗
ValerianMixed
“I've tried boosting GABA with Passion Flower, Valerian, L-Theanine, B-complex and more. No effect.”Source discussion ↗
ValerianMixed
“I then tried raising GABA using L-Theanine, GABA, Valerian, Passion Flower etc. No effect. None.”Source discussion ↗
ValerianMixed
“There are peer reviewed studies that absolutely document benzo like withdrawals from valerian. I definitely think it's safe to say that benzo withdrawals are worse...I can't say there was even a real withdrawal syndrome in the first place.”Source discussion ↗