What people actually say
1,296 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
Alcohol CessationMostly positive
“cut out alch... weed, processed foods, soda, processed sugar as much as you can. For me, weed was fucking up my mental state, memory, and sleep cycle.”Source discussion ↗
Alcohol CessationMostly positive
“Drinking probably contributes, but I went dry for ~10 months to attempt to solve the sleep issue and it only slightly improved.”Source discussion ↗
Alcohol CessationMostly positive
“Quitting alcohol completely ... the most obvious aspect was for my sleep hygiene.”Source discussion ↗
Alcohol CessationMostly positive
“Oh, and I gave up alcohol, almost completely, that helped a lot too.”Source discussion ↗
ProgesteroneMostly positive
“I used to struggle with this as a perimenopause symptom. Progesterone has helped a lot.”Source discussion ↗
ProgesteroneMostly positive
“I got on HRT, specifically oestrogen patches and suppository as well as a progesterone tablet just before bed, which helped my sleep a lot.”Source discussion ↗
ProgesteroneMostly positive
“200mg progesterone (I am a 52 yr old woman in perimenopause, so this isn't for men) I now sleep amazingly well”Source discussion ↗
ProgesteroneMostly positive
“Progesterone!!!! Works wonder for sleep. I was the same”Source discussion ↗
GhbMostly positive
“My silver bullet for sleep is GHB (2.5ml) + a calcium channel blocker like gabapentin (150mg) or pregabalin (50-75mg)”Source discussion ↗
GhbMostly positive
“GHB is god tier for sleep though. I doubt there's an actual better drug out there for sleep than GHB.”Source discussion ↗
GhbMostly positive
“GHB, for instance, makes me feel a little off for a few days after.”Source discussion ↗
GhbMostly positive
“I've used it daily (evenings only) for 4-5 years now, with surprisingly few side effects and no withdrawals when I go on holiday.”Source discussion ↗
Ipamorelin/CJC-1295Mixed
“the improvements in sleep quality made a dramatic improvement in my overall quality of life and the impact was noticeable within a week.”Source discussion ↗
Ipamorelin/CJC-1295Mixed
“I did a cycle for 4 months and didn’t see much for results... developed some carpel tunnel side effects, water retention”Source discussion ↗
Ipamorelin/CJC-1295Mixed
“IPA and CJC have been life changing for my injuries with non of the shitty side effects”Source discussion ↗
Ipamorelin/CJC-1295Mixed
“Been taking IPA/CJC for about 2 weeks. Can’t say it does anything but gives me hot flashes after taking, really.”Source discussion ↗
VortioxetineMostly negative
“I feel a lot better with antidepressants, I can remember things again... I can sleep again... I have again libido and I haven't suicide ideation anymore”Source discussion ↗
VortioxetineMostly negative
“Vortioxetine ended up improving my mood, lowering my anxiety and had much less emotional and sexual side effects... it also started to decrease my motivation and cause lethargy.”Source discussion ↗
VortioxetineMostly negative
“I recently came off vortioxetine 20mg because it made my anxiety a lot worse.”Source discussion ↗
VortioxetineMostly negative
“testing out depression and anxiety medicines, 10mg brintellix (trintellix/vortioxetine) and 250-500mcg xanor (xanax/alprazolam). They seem to not help me after 1,5 months.”Source discussion ↗
Siberian GinsengMostly positive
“After consistently taking this stimulant for a week or so, I have a lot more energy, I'm sleeping better and I just generally am in a better mood.”Source discussion ↗
Siberian GinsengMostly positive
“Siberian Ginseng (Eleuthero Root) is another supplement I took for along time. In lower doses it seems to be good at reducing anxiety without any sedation.”Source discussion ↗
Siberian GinsengMostly positive
“I'm a big proponent of siberian ginseng, Eleutherococcus senticosus. Done well for my dad who works 85 a week in management.”Source discussion ↗
Siberian GinsengMostly positive
“It certainly has helped me, no end. It's helped with the host of sleep problems and waking in the night”Source discussion ↗
DoxylamineMostly positive
“I've been on OTC sleeping pills (e.g. Unisom) ever since. I've tried numerous times to get off but then I'll only get 30 mins to 2 hrs of sleep per night without it.”Source discussion ↗
DoxylamineMostly positive
“I've tried a bunch of supplements and none of them work to help me stay asleep”Source discussion ↗
DoxylamineMostly positive
“The best meds for my sleep are THC and surprisingly doxylamine. Out of everything so far, doxylamine is probably the most helpful.”Source discussion ↗
DoxylamineMostly positive
“unisom works really well for me even though i am aware that its not really a biohack”Source discussion ↗
ParaxanthineMostly positive
“200 mg seems to be the perfect amount for me and has a shorter half life than caffeine with not noticeable crash.”Source discussion ↗
ParaxanthineMostly positive
“Paraxanthine, one of the metabolites of caffeine, has a lot of the positive qualities of caffeine and fewer of the side effects. I'm a month into experimenting with it and could see it replacing caffeine for me.”Source discussion ↗
ParaxanthineMostly positive
“I've taken paraxanthine for over a year now and definitely recommend it. Doesn't affect sleep as much and results in fewer jitters, palpitations, and feelings of anxiety”Source discussion ↗
ParaxanthineMostly positive
“I enjoy paraxanthine, as a metabolite of caffeine it is still a stimulant but the half life is much shorter... It seems to be a less anxious energy”Source discussion ↗
CalmaidMostly positive
“I'd suggest trying CalmAid (silexan) - it has evidence for anxiety, it's non-sedating, works within ~15 minutes and doesn't have the risk of the common alternatives.”Source discussion ↗
CalmaidMostly positive
“And they've been utterly amazing. I can think clearly now. I didn't even realize how much anxiety was plaguing me.”Source discussion ↗
CalmaidMostly positive
“I'd drop the SJW and go with CalmAid (Silexan) since it actually has specific evidence for anxiety and does not interact with at least one type of oral contraceptive pill.”Source discussion ↗
CalmaidMostly positive
“If you're looking for something else to try for anxiety, I'd recommend CalmAid...Works within 15 minutes...Most people dose once per day as needed.”Source discussion ↗
Baikal SkullcapMostly positive
“significantly calming without inducing much if any lethargy. Futhermore, the subjective effects I personally experience, include a very nice mood boost and I feel like I can focus better after taking it.”Source discussion ↗
Baikal SkullcapMostly positive
“Baikal skullcap works wonders for me, 250-500mg per day and it really does its job well”Source discussion ↗
Baikal SkullcapMostly positive
“My ultimate stack for anxiety is lemon balm,baikal skull cap,Ksm66 ,Isoliquitergenin and pregnenolone”Source discussion ↗
Baikal SkullcapMostly positive
“I'd use Baikal for that, my verbal fluency and short term memory usage is insane with it.”Source discussion ↗