What people actually say

“I have been taking methylfolate with methylcobalamin for almost two months now and my prefrontal abilities with respect to planning and stress management have improved dramatically.”

“I tried so many things for depression like saffron rhodiola tyrosine omega 3 methylfolate B12 taurine theanine NAC inositol b complex magnesium nothing helps it.”

“The first couple times I took methylfolate I felt better and more energetic than ever before...after about 6 months experimenting I would say it has had a good overall effect and I do feel quite a bit better.”

“I take it anyway and it works fine. I take a b complex about once per week, and another dose of 400mcg methylfolate + 500mcg methylb12 once per week.”

“MethylPro L-Methylfolate 15mg + Cofactors (B6, B12, magnesium). I felt completely cracked out on this. Really jittery, and couldn't sleep.”

“p-5-p, folic acid and magnesium oil (topical) have helped me a lot with regards to anxiety, sleep quality, and motivation.”

“I felt hardly anything from Thorne's '5-MTHF' (L-5) or loading up on folate in general.”

“I couldn't take any amount of methyl-B12 or Methylfolate without feeling like absolute crap.”

“I completely stopped everything and tried taking B9 (folate) for about 2 weeks, but I didn’t notice any improvement.”

“I slept the best I have in months and woke up feeling calm and collected no anxiety or restlessness.”

“every time I take folate supplements, methylfolate or any form, I feel really depressed, more anxious, and have racing mind/thoughts.”

“I've taken this before, helped me with cardio and made me feel calm, not jittery and aided my focus.”

“METHYLFOLATE. As I suffer from the MTHFR-mutation this one really had the most "psychoactive" and significantly noticeable effect on my depression, mood and social anxiety.”

“the most effective and sustainable pill type treatment for my anxiety is L-Methylfolate... It changed my life from the first day i took it.”

“I started heavily supplementing Methylfolate (the product of said enzyme). It has helped my mental health and energy immensely.”

“Methylcobalamin+methylfolate...I have been supplementing with different kinds of vitamin b since and I have never felt better.”

“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”

“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”

“Taking SAM-e completely changed my life from total lethargy with the only relief being Adderall or Ritalin to being a functional person, no side effects noticed and I only have to cycle it occasionally.”

“SAMe and agmatine sulfate over the past year to be the two most noticeably helpful supplements i have ever taken for baseline energy/mood.”

“Took me years to feel normal. Back then I used SAMe to help me.”

“Low and behold it actually worked. Within five days I noticed a difference. The headaches are gone and I wake up everyday feeling refreshed.”

“It helped mood and motivation, had more of a desire to get out and do things like be social. Felt like a weaker Wellbutrin to me.”

“I was taking Sam-E for an energy boost when I go for a ride. I no longer take that stuff though because I've heard it disrupts sleep patterns.”

“I had mild success with the supplement SAM-e. It definitely is stimulating—so should be taken in the AM—but no where near what any dedicated focus OTC peptide or supplement blends tend to do to me.”

“sam-e - I'm not yet sure how this makes me feel better, because I take it since few days, but works wonders.”

“I've had some success with SAM-e and Agmatine for anxiety, though these are not ssris.”

“Another great stack I was into awhile back was SAMe+CDP choline+fasoracetam. That's definitely a 1-2 week stack but it worked *very* nicely for a high-productivity, focused edge.”

“I felt more mental clarity and less brain fog after taking it for a month.”

“SAM-e alone had no sleep shortening effect. At the end my natural sleep length increased to ~8.5h. At that point I resumed taking SAM-e.”

“I have quit nicotine for a while now with help from what I believe is SAMe doing most of the heavy lifting with my mood... Starting at 200mg then working up to 400 Mg (I’m very happy with the results).”

“I've seen some amazing improvement in such a short amount of time (even better than SSRI!). After a week, I decided to stop...started experiencing a horrible spike in OCD and anxiety.”

“The above supplements have worked amazingly for my brain fog and motivation.”

“The Thorne Quercetin has helped me a lot with seasonal allergies. I'd go as far as to say it had been more effective for me than either Claritin or Zyrtec.”

“EGCG (green tea extact) and quercetin may two others to look into. Paired with NMN and 7,8DHF it seems to compound the energy improvements of NMN for me by a lot.”

“Her kidney specialist said up to 500mg quercetin is fine per day, may actually be beneficial...I like NMN, I believe it's best paired with something like quercetin or another cd38 inhibitor for better absorption.”

“Quercetin and bromelain, Vitamin K and D, astaxanthan, fish oil, turmeric, boron, msm, and coq10. I have osteoarthritis and this combo has been helping with the pain.”

“Quercetin. I had it against Covid, but apparently it is also good for allergies. It worked.”

“I feel like it does help against allergies and cold and flu season.”

“I use it with quercetin because I heard it works in synergy”