PlainPill

What people actually say

6,092 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
TamoxifenMostly positive
“On the first PCT the only side effect I had was a literal unbearable libido, and I do truly mean literal”
Source discussion ↗
TamoxifenMostly positive
“Clomid and or nolva I feel made my distant vision a little hazy”
Source discussion ↗
TamoxifenMostly positive
“I recommend low dose tamoxifen aka Nolvadex at 10 mg day. It will increase your testosterone in measurable amounts.”
Source discussion ↗
TamoxifenMostly positive
“Yes I did get very suppressed so took Nolva afterwards and that sorted it, bloods showed low T.”
Source discussion ↗
TamoxifenMostly positive
“I didn’t get back up to baseline (got bloods) until I introduced nolvadex. ... Never. Use. Nolva. For. Sarms.”
Source discussion ↗
TamoxifenMostly positive
“continued the tamoxifen at 5mg ED for another 2 weeks. At the end of those two weeks I did bloodwork again and was just about back to baseline figures.”
Source discussion ↗
TamoxifenMostly positive
“All these symptoms cleared in week 5 when I incorporated the SARM + SERM protocol (ran Nolva).”
Source discussion ↗
TamoxifenMostly positive
“Taking Nolva in cycle isn’t really a good idea either from what I know, can affect your gains and possibly cause sides.”
Source discussion ↗
FolateMostly positive
“I have been taking methylfolate with methylcobalamin for almost two months now and my prefrontal abilities with respect to planning and stress management have improved dramatically.”
Source discussion ↗
FolateMostly positive
“I tried so many things for depression like saffron rhodiola tyrosine omega 3 methylfolate B12 taurine theanine NAC inositol b complex magnesium nothing helps it.”
Source discussion ↗
FolateMostly positive
“The first couple times I took methylfolate I felt better and more energetic than ever before...after about 6 months experimenting I would say it has had a good overall effect and I do feel quite a bit better.”
Source discussion ↗
FolateMostly positive
“I take it anyway and it works fine. I take a b complex about once per week, and another dose of 400mcg methylfolate + 500mcg methylb12 once per week.”
Source discussion ↗
FolateMostly positive
“MethylPro L-Methylfolate 15mg + Cofactors (B6, B12, magnesium). I felt completely cracked out on this. Really jittery, and couldn't sleep.”
Source discussion ↗
FolateMostly positive
“p-5-p, folic acid and magnesium oil (topical) have helped me a lot with regards to anxiety, sleep quality, and motivation.”
Source discussion ↗
FolateMostly positive
“I felt hardly anything from Thorne's '5-MTHF' (L-5) or loading up on folate in general.”
Source discussion ↗
FolateMostly positive
“I couldn't take any amount of methyl-B12 or Methylfolate without feeling like absolute crap.”
Source discussion ↗
FolateMostly positive
“I completely stopped everything and tried taking B9 (folate) for about 2 weeks, but I didn’t notice any improvement.”
Source discussion ↗
FolateMostly positive
“I slept the best I have in months and woke up feeling calm and collected no anxiety or restlessness.”
Source discussion ↗
FolateMostly positive
“every time I take folate supplements, methylfolate or any form, I feel really depressed, more anxious, and have racing mind/thoughts.”
Source discussion ↗
FolateMostly positive
“I've taken this before, helped me with cardio and made me feel calm, not jittery and aided my focus.”
Source discussion ↗
FolateMostly positive
“METHYLFOLATE. As I suffer from the MTHFR-mutation this one really had the most "psychoactive" and significantly noticeable effect on my depression, mood and social anxiety.”
Source discussion ↗
FolateMostly positive
“the most effective and sustainable pill type treatment for my anxiety is L-Methylfolate... It changed my life from the first day i took it.”
Source discussion ↗
FolateMostly positive
“I started heavily supplementing Methylfolate (the product of said enzyme). It has helped my mental health and energy immensely.”
Source discussion ↗
FolateMostly positive
“Methylcobalamin+methylfolate...I have been supplementing with different kinds of vitamin b since and I have never felt better.”
Source discussion ↗
SAM-EMostly positive
“I also take SAM-e in the morning (200mg or 400mg per day depending on how I'm feeling) for my general depression/anxiety.”
Source discussion ↗
SAM-EMostly positive
“I just started taking Sam-e and it’s helped with my ADHD and depression tremendously.”
Source discussion ↗
SAM-EMostly positive
“Taking SAM-e completely changed my life from total lethargy with the only relief being Adderall or Ritalin to being a functional person, no side effects noticed and I only have to cycle it occasionally.”
Source discussion ↗
SAM-EMostly positive
“SAMe and agmatine sulfate over the past year to be the two most noticeably helpful supplements i have ever taken for baseline energy/mood.”
Source discussion ↗
SAM-EMostly positive
“Took me years to feel normal. Back then I used SAMe to help me.”
Source discussion ↗
SAM-EMostly positive
“Low and behold it actually worked. Within five days I noticed a difference. The headaches are gone and I wake up everyday feeling refreshed.”
Source discussion ↗
SAM-EMostly positive
“It helped mood and motivation, had more of a desire to get out and do things like be social. Felt like a weaker Wellbutrin to me.”
Source discussion ↗
SAM-EMostly positive
“I was taking Sam-E for an energy boost when I go for a ride. I no longer take that stuff though because I've heard it disrupts sleep patterns.”
Source discussion ↗
SAM-EMostly positive
“I had mild success with the supplement SAM-e. It definitely is stimulating—so should be taken in the AM—but no where near what any dedicated focus OTC peptide or supplement blends tend to do to me.”
Source discussion ↗
SAM-EMostly positive
“sam-e - I'm not yet sure how this makes me feel better, because I take it since few days, but works wonders.”
Source discussion ↗
SAM-EMostly positive
“I've had some success with SAM-e and Agmatine for anxiety, though these are not ssris.”
Source discussion ↗
SAM-EMostly positive
“Another great stack I was into awhile back was SAMe+CDP choline+fasoracetam. That's definitely a 1-2 week stack but it worked *very* nicely for a high-productivity, focused edge.”
Source discussion ↗
SAM-EMostly positive
“I felt more mental clarity and less brain fog after taking it for a month.”
Source discussion ↗
SAM-EMostly positive
“SAM-e alone had no sleep shortening effect. At the end my natural sleep length increased to ~8.5h. At that point I resumed taking SAM-e.”
Source discussion ↗
SAM-EMostly positive
“I have quit nicotine for a while now with help from what I believe is SAMe doing most of the heavy lifting with my mood... Starting at 200mg then working up to 400 Mg (I’m very happy with the results).”
Source discussion ↗
SAM-EMostly positive
“I've seen some amazing improvement in such a short amount of time (even better than SSRI!). After a week, I decided to stop...started experiencing a horrible spike in OCD and anxiety.”
Source discussion ↗
User reports — what people say about supplements — PlainPill