L-Citrulline vs Propranolol for heart & lipids
Short answer: For heart & lipids, more users report improvement with Propranolol — 100% of 12 reports, versus 95% of 22 for L-Citrulline.
L-Citrulline has 14 meta-analyses and 101 randomized trials on PubMed; Propranolol has 268 and 1,961.
Based on 231 reports about L-Citrulline and 166 about Propranolol. Not medical advice.
| L-Citrulline Supplement | Propranolol Medication | |
|---|---|---|
| Users say it helped | 77%helped99 reports · medium confidence | 79%helped105 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 14 / 101 | 268 / 1,961 |
| Mainly used for | ||
| Anxiety % reporting improvement | 100% (2) | 94% (101) |
| Libido % reporting improvement | 98% (48) | — |
| Performance % reporting improvement | 98% (45) | 100% (2) |
| Heart & lipids % reporting improvement | 95% (22) | 100% (12) |
| Energy % reporting improvement | 100% (11) | — |
| Common side effects | cold sore, dizziness, headache, increased urination | insomnia, depression, fatigue, weight gain |
| Typical dose reported | 8 g / 3x/week | Not listed |
Foods rich in polyphenols and nitrate provide trivial benefits for endurance exercise performance, although these effects may be food dependent. Highly trained endurance athletes do not appear to benefit from consuming nitrate-rich foods but may benefit from polyphenol consumption. Further research into food sources, dosage and supplementation duration to optimise the ergogenic response to polyphenol consumption is warranted. Further studies should evaluate whether differential sex-based responses to nitrate and polyphenol consumption are attributable to physiological differences or sample siz
J Int Soc Sports Nutr, 2021 ↗“Something I found that makes my meds work way better is Citrulline 2g + Arginine 2g twice daily.”
In this systematic review and network meta-analysis, mirtazapine, biperiden, and vitamin B6 were associated with the greatest efficacy for AIA, with vitamin B6 having the best efficacy and tolerance profile. Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.
JAMA Netw Open, 2024 ↗“I just got a script for propranolol that I can take as needed and it's been a game changer.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate