PlainPill

L-Citrulline vs Propranolol for heart & lipids

Short answer: For heart & lipids, more users report improvement with Propranolol — 100% of 12 reports, versus 95% of 22 for L-Citrulline.

L-Citrulline has 14 meta-analyses and 101 randomized trials on PubMed; Propranolol has 268 and 1,961.

Based on 231 reports about L-Citrulline and 166 about Propranolol. Not medical advice.

L-Citrulline
Supplement
Propranolol
Medication
Users say it helped77%helped99 reports · medium confidence79%helped105 reports · high confidence
Verdict
Mostly positive
Mostly positive
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs14 / 101268 / 1,961
Mainly used for
Anxiety
% reporting improvement
100% (2)94% (101)
Libido
% reporting improvement
98% (48)—
Performance
% reporting improvement
98% (45)100% (2)
Heart & lipids
% reporting improvement
95% (22)100% (12)
Energy
% reporting improvement
100% (11)—
Common side effectscold sore, dizziness, headache, increased urinationinsomnia, depression, fatigue, weight gain
Typical dose reported8 g / 3x/weekNot listed
L-Citrulline
Latest review conclusion

Foods rich in polyphenols and nitrate provide trivial benefits for endurance exercise performance, although these effects may be food dependent. Highly trained endurance athletes do not appear to benefit from consuming nitrate-rich foods but may benefit from polyphenol consumption. Further research into food sources, dosage and supplementation duration to optimise the ergogenic response to polyphenol consumption is warranted. Further studies should evaluate whether differential sex-based responses to nitrate and polyphenol consumption are attributable to physiological differences or sample siz

J Int Soc Sports Nutr, 2021 ↗
What a user said
“Something I found that makes my meds work way better is Citrulline 2g + Arginine 2g twice daily.”
Full L-Citrulline profile →
Propranolol
Latest review conclusion

In this systematic review and network meta-analysis, mirtazapine, biperiden, and vitamin B6 were associated with the greatest efficacy for AIA, with vitamin B6 having the best efficacy and tolerance profile. Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.

JAMA Netw Open, 2024 ↗
What a user said
“I just got a script for propranolol that I can take as needed and it's been a game changer.”
Full Propranolol profile →

Related comparisons

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate