PlainPill

Melanotan Ii vs Vitamin C for skin & hair

Short answer: For skin & hair, more users report improvement with Vitamin C — 97% of 29 reports, versus 88% of 84 for Melanotan Ii.

Melanotan Ii has 1 meta-analyses and 1 randomized trials on PubMed; Vitamin C has 738 and 2,072.

Based on 186 reports about Melanotan Ii and 928 about Vitamin C. Not medical advice.

Melanotan Ii
Peptide
Vitamin C
Supplement
Users say it helped60%helped115 reports · high confidence64%helped204 reports · high confidence
Verdict
Mixed
Mostly positive
ResearchBResearch: ModerateAResearch: Strong
Meta-analyses / RCTs1 / 1738 / 2,072
Mainly used for
Skin & hair
% reporting improvement
88% (84)97% (29)
Libido
% reporting improvement
96% (48)100% (2)
Immunity
% reporting improvement
100% (3)90% (40)
Energy
% reporting improvement
—94% (34)
Mood
% reporting improvement
40% (5)88% (25)
Common side effectsnausea, flushing, freckles, moleskidney stones, stomach issues, insomnia, bone pain
Typical dose reportedNot listed2000 mg / daily
Melanotan Ii
Latest review conclusion

Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.

Int J Obes (Lond), 2014 ↗
What a user said
“I've found that getting sun within 3-12 hours will produce the desired result.”
Full Melanotan Ii profile →
Vitamin C
Latest review conclusion

The failure of vitamin C supplementation to reduce the incidence of colds in the general population indicates that routine vitamin C supplementation is not justified, yet vitamin C may be useful for people exposed to brief periods of severe physical exercise. Regular supplementation trials have shown that vitamin C reduces the duration of colds, but this was not replicated in the few therapeutic trials that have been carried out. Nevertheless, given the consistent effect of vitamin C on the duration and severity of colds in the regular supplementation studies, and the low cost and safety, it m

Cochrane Database Syst Rev, 2013 ↗
What a user said
“I know people say you get enough vitamin C from diet but I feel and look better when I supplement it.”
Full Vitamin C profile →

Related comparisons

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate