PlainPill

Collagen vs Melanotan Ii for skin & hair

Short answer: For skin & hair, more users report improvement with Collagen — 96% of 71 reports, versus 88% of 84 for Melanotan Ii.

Collagen has 9 meta-analyses and 22 randomized trials on PubMed; Melanotan Ii has 1 and 1.

Based on 292 reports about Collagen and 186 about Melanotan Ii. Not medical advice.

Collagen
Supplement
Melanotan Ii
Peptide
Users say it helped56%helped120 reports · high confidence60%helped115 reports · high confidence
Verdict
Mixed
Mixed
ResearchAResearch: StrongBResearch: Moderate
Meta-analyses / RCTs9 / 221 / 1
Mainly used for
Skin & hair
% reporting improvement
96% (71)88% (84)
Libido
% reporting improvement
—96% (48)
Recovery
% reporting improvement
94% (47)—
Pain & inflammation
% reporting improvement
92% (24)—
Weight loss
% reporting improvement
—100% (12)
Common side effectsfatigue, insomnia, drowsiness, histamine episodenausea, flushing, freckles, moles
Typical dose reported7 g / dailyNot listed
Collagen
Latest review conclusion

The findings of improved hydration and elasticity were also confirmed in the subgroup meta-analysis. Based on results, ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration.

Int J Dermatol, 2021 ↗
What a user said
“Within hours of consumption my consistent upper back pain is literally gone, but along with it comes dizziness and a feeling of aloofness.”
Full Collagen profile →
Melanotan Ii
Latest review conclusion

Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.

Int J Obes (Lond), 2014 ↗
What a user said
“I've found that getting sun within 3-12 hours will produce the desired result.”
Full Melanotan Ii profile →

Related comparisons

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate