Melanotan Ii vs Tadalafil for libido
Short answer: For libido, more users report improvement with Melanotan Ii — 96% of 47 reports, versus 91% of 82 for Tadalafil.
Melanotan Ii has 1 meta-analyses and 1 randomized trials on PubMed; Tadalafil has 120 and 347.
Based on 145 reports about Melanotan Ii and 214 about Tadalafil. Not medical advice.
| Melanotan Ii Peptide | Tadalafil Medication | |
|---|---|---|
| User score | 61 | 65 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 63% | 78% |
| Reports | 145 | 214 |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 1 / 1 | 120 / 347 |
| Mainly used for | ||
| Weight loss % reporting improvement | 100% (11) | — |
| Appetite % reporting improvement | 67% (6) | — |
| Focus % reporting improvement | — | 88% (8) |
| Energy % reporting improvement | — | 100% (6) |
| Sleep % reporting improvement | 0% (4) | 100% (4) |
| Anxiety % reporting improvement | — | 75% (4) |
| Mood % reporting improvement | 40% (5) | 100% (9) |
| Performance % reporting improvement | 100% (5) | 97% (61) |
| Recovery % reporting improvement | — | 100% (6) |
| Pain & inflammation % reporting improvement | — | 100% (2) |
| Libido % reporting improvement | 96% (47) | 91% (82) |
| Hormones % reporting improvement | — | 100% (3) |
| Blood sugar % reporting improvement | — | 100% (2) |
| Heart & lipids % reporting improvement | 33% (3) | 100% (17) |
| Skin & hair % reporting improvement | 91% (67) | — |
| Immunity % reporting improvement | 100% (2) | — |
| Longevity % reporting improvement | — | 100% (2) |
| Common side effects | nausea, flushing, freckles, darkened moles | headache, stuffy nose, heartburn, lower back |
| Typical dose reported | Not listed | 2.5-5 mg / daily or 5-10 mg every other day |
Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.
Int J Obes (Lond), 2014 ↗“I've found that getting sun within 3-12 hours will produce the desired result.”
Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients' sexual confidence. Furthermore, patients and their partners prefer tadalafil to sildenafil. Hence, tadalafil may be a better choice for ED treatment.
Int Urol Nephrol, 2017 ↗“After a week of 2.5 mg twice a day, this is my favourite drug ever. My brain fog has gone...My mood is so much better, similar to an SSRI but without the flat feeling.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate