L-Citrulline vs Melanotan Ii for libido
Short answer: For libido, users rate them about the same: 97% report improvement with L-Citrulline (37 reports) and 96% with Melanotan Ii (47 reports).
L-Citrulline has 14 meta-analyses and 101 randomized trials on PubMed; Melanotan Ii has 1 and 1.
Based on 181 reports about L-Citrulline and 145 about Melanotan Ii. Not medical advice.
| L-Citrulline Supplement | Melanotan Ii Peptide | |
|---|---|---|
| User score | 57 | 61 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 76% | 63% |
| Reports | 181 | 145 |
| Research | AResearch: Strong | BResearch: Moderate |
| Meta-analyses / RCTs | 14 / 101 | 1 / 1 |
| Mainly used for | ||
| Weight loss % reporting improvement | — | 100% (11) |
| Appetite % reporting improvement | — | 67% (6) |
| Focus % reporting improvement | 67% (3) | — |
| Energy % reporting improvement | 100% (7) | — |
| Sleep % reporting improvement | — | 0% (4) |
| Anxiety % reporting improvement | 100% (2) | — |
| Mood % reporting improvement | 100% (2) | 40% (5) |
| Performance % reporting improvement | 97% (30) | 100% (5) |
| Recovery % reporting improvement | 100% (3) | — |
| Pain & inflammation % reporting improvement | 100% (2) | — |
| Libido % reporting improvement | 97% (37) | 96% (47) |
| Hormones % reporting improvement | 50% (2) | — |
| Heart & lipids % reporting improvement | 94% (16) | 33% (3) |
| Skin & hair % reporting improvement | — | 91% (67) |
| Immunity % reporting improvement | — | 100% (2) |
| Common side effects | dizziness, headache, eye bags, tooth damage | nausea, flushing, freckles, darkened moles |
| Typical dose reported | 8 g / 3x/week | Not listed |
Foods rich in polyphenols and nitrate provide trivial benefits for endurance exercise performance, although these effects may be food dependent. Highly trained endurance athletes do not appear to benefit from consuming nitrate-rich foods but may benefit from polyphenol consumption. Further research into food sources, dosage and supplementation duration to optimise the ergogenic response to polyphenol consumption is warranted. Further studies should evaluate whether differential sex-based responses to nitrate and polyphenol consumption are attributable to physiological differences or sample siz
J Int Soc Sports Nutr, 2021 ↗“Something I found that makes my meds work way better is Citrulline 2g + Arginine 2g twice daily.”
Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.
Int J Obes (Lond), 2014 ↗“I've found that getting sun within 3-12 hours will produce the desired result.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate