Melanotan Ii vs Tretinoin for skin & hair
Short answer: For skin & hair, users rate them about the same: 88% report improvement with Melanotan Ii (84 reports) and 91% with Tretinoin (35 reports).
Melanotan Ii has 1 meta-analyses and 1 randomized trials on PubMed; Tretinoin has 76 and 265.
Based on 186 reports about Melanotan Ii and 50 about Tretinoin. Not medical advice.
| Melanotan Ii Peptide | Tretinoin Medication | |
|---|---|---|
| Users say it helped | 60%helped115 reports · high confidence | 91%helped23 reports · medium confidence |
| Verdict | Mixed | Mostly positive |
| Research | BResearch: Moderate | AResearch: Strong |
| Meta-analyses / RCTs | 1 / 1 | 76 / 265 |
| Mainly used for | ||
| Skin & hair % reporting improvement | 88% (84) | 91% (35) |
| Libido % reporting improvement | 96% (48) | — |
| Weight loss % reporting improvement | 100% (12) | — |
| Appetite % reporting improvement | 57% (7) | — |
| Mood % reporting improvement | 40% (5) | — |
| Common side effects | nausea, flushing, freckles, moles | sunburn, irritation, skin peeling |
| Typical dose reported | Not listed | Not listed |
Almost all studies are in the preclinical phase. There are currently no effective clinical treatments for MC4R-deficient obese patients, although MC4R agonists are being developed and are entering phase I and II trials.
Int J Obes (Lond), 2014 ↗“I've found that getting sun within 3-12 hours will produce the desired result.”
These guidelines provide evidence-based recommendations for the management of acne vulgaris.
J Am Acad Dermatol, 2024 ↗“I have gotten good result on the acne front with tretinoin and azelaic acid.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate