L-Lysine vs Thymosin Alpha-1 for immunity
Short answer: For immunity, more users report improvement with L-Lysine — 100% of 9 reports, versus 90% of 21 for Thymosin Alpha-1.
L-Lysine has 7 meta-analyses and 59 randomized trials on PubMed; Thymosin Alpha-1 has 11 and 35.
Based on 53 reports about L-Lysine and 71 about Thymosin Alpha-1. Not medical advice.
| L-Lysine Supplement | Thymosin Alpha-1 Peptide | |
|---|---|---|
| Users say it helped | 65%helped21 reports · medium confidence | 70%helped23 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 7 / 59 | 11 / 35 |
| Mainly used for | ||
| Immunity % reporting improvement | 100% (9) | 90% (21) |
| Pain & inflammation % reporting improvement | — | 80% (5) |
| Common side effects | stomach issues | flushing, rapid hr, nausea, unwell feeling |
| Typical dose reported | 2 g / before bed | Not listed |
Based primarily on case reports ornithine levels can be reduced by using a protein restricted diet, pyridoxine supplementation (variation-dependent) and/or lysine supplementation. The lack of pre-defined clinical outcome measures and structural follow-up in all included studies impeded conclusions on clinical effectiveness. Future research should be aimed at 1) Unravelling the OAT biochemical pathway to identify other possible pathologic metabolites besides ornithine, 2) Pre-defining GACR specific clinical outcome measures, and 3) Establishing an international historical cohort.
Mol Genet Metab, 2021 ↗“Finally, I started to take L-lysine for a different issue. Immediately I saw that I could lay my head down at night and go to sleep like I could before. That was several months ago and I continue to sleep regularly.”
Based on the results of the included studies, there is insufficient evidence to support or refute the effectiveness of different interventions for avulsed and replanted permanent front teeth. The overall quality of existing evidence was very low, and therefore great caution should be exercised when generalising the results of the included trials. There is urgent need for further well-designed randomised controlled trials.
Cochrane Database Syst Rev, 2019 ↗“I started peptide therapy a little over a month ago for traumatic brain injury. The results I've experienced have been tremendous. I'm getting brain function back that has been gone for over a decade.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate