PlainPill

L-Lysine vs Quercetin for immunity

Short answer: For immunity, users rate them about the same: 100% report improvement with L-Lysine (9 reports) and 100% with Quercetin (15 reports).

L-Lysine has 7 meta-analyses and 59 randomized trials on PubMed; Quercetin has 207 and 232.

Based on 53 reports about L-Lysine and 280 about Quercetin. Not medical advice.

L-Lysine
Supplement
Quercetin
Supplement
Users say it helped65%helped21 reports · medium confidence58%helped67 reports · medium confidence
Verdict
Mostly positive
Mixed
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs7 / 59207 / 232
Mainly used for
Immunity
% reporting improvement
100% (9)100% (15)
Pain & inflammation
% reporting improvement
—67% (15)
Focus
% reporting improvement
100% (2)100% (7)
Energy
% reporting improvement
—100% (8)
Sleep
% reporting improvement
50% (2)60% (5)
Common side effectsstomach issuesinsomnia, jitteriness, anxiety, stimulation
Typical dose reported2 g / before bed500-1000 mg
L-Lysine
Latest review conclusion

Based primarily on case reports ornithine levels can be reduced by using a protein restricted diet, pyridoxine supplementation (variation-dependent) and/or lysine supplementation. The lack of pre-defined clinical outcome measures and structural follow-up in all included studies impeded conclusions on clinical effectiveness. Future research should be aimed at 1) Unravelling the OAT biochemical pathway to identify other possible pathologic metabolites besides ornithine, 2) Pre-defining GACR specific clinical outcome measures, and 3) Establishing an international historical cohort.

Mol Genet Metab, 2021 ↗
What a user said
“Finally, I started to take L-lysine for a different issue. Immediately I saw that I could lay my head down at night and go to sleep like I could before. That was several months ago and I continue to sleep regularly.”
Full L-Lysine profile →
Quercetin
Latest review conclusion

The results of a meta-analysis of 12 RCTs indicate that TCM intervention can improve the clinical treatment efficacy of CAG. NPAs identified seven hub TCM and 13 target genes associated with their actions, while bioinformatics analysis identified two DEGs between normal and CAG gastric tissues. Finally, molecular docking was employed to reveal the mechanism of action of the active molecules in TCM on the DEGs. These findings not only reveal the mechanisms of action of the active components of the TCMs, but also provide support for the development of new drugs, ultimately blocking the progressi

Ann Med, 2023 ↗
What a user said
“Quercetin and bromelain, Vitamin K and D, astaxanthan, fish oil, turmeric, boron, msm, and coq10. I have osteoarthritis and this combo has been helping with the pain.”
Full Quercetin profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate