L-Lysine vs Vitamin D for immunity
Short answer: For immunity, users rate them about the same: 100% report improvement with L-Lysine (9 reports) and 98% with Vitamin D (94 reports).
L-Lysine has 7 meta-analyses and 59 randomized trials on PubMed; Vitamin D has 3,251 and 4,560.
Based on 53 reports about L-Lysine and 3,058 about Vitamin D. Not medical advice.
| L-Lysine Supplement | Vitamin D Supplement | |
|---|---|---|
| Users say it helped | 65%helped21 reports · medium confidence | 67%helped1,101 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 7 / 59 | 3,251 / 4,560 |
| Mainly used for | ||
| Mood % reporting improvement | — | 88% (393) |
| Energy % reporting improvement | — | 87% (255) |
| Sleep % reporting improvement | 50% (2) | 52% (119) |
| Immunity % reporting improvement | 100% (9) | 98% (94) |
| Anxiety % reporting improvement | 100% (2) | 64% (90) |
| Common side effects | stomach issues | insomnia, anxiety, hypercalcemia, nausea |
| Typical dose reported | 2 g / before bed | 10,000-20,000 IU / daily |
Based primarily on case reports ornithine levels can be reduced by using a protein restricted diet, pyridoxine supplementation (variation-dependent) and/or lysine supplementation. The lack of pre-defined clinical outcome measures and structural follow-up in all included studies impeded conclusions on clinical effectiveness. Future research should be aimed at 1) Unravelling the OAT biochemical pathway to identify other possible pathologic metabolites besides ornithine, 2) Pre-defining GACR specific clinical outcome measures, and 3) Establishing an international historical cohort.
Mol Genet Metab, 2021 ↗“Finally, I started to take L-lysine for a different issue. Immediately I saw that I could lay my head down at night and go to sleep like I could before. That was several months ago and I continue to sleep regularly.”
These results indicate that the prevalence of vitamin D deficiency was more elevated in obese subjects. The vitamin D deficiency was associated with obesity irrespective of age, latitude, cut-offs to define vitamin D deficiency and the Human Development Index of the study location.
Obes Rev, 2015 ↗“First thing I noticed was my mood & libido, I have more 'feeling/sensitivity' down there.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate