Creatine vs Modafinil for focus
Short answer: For focus, more users report improvement with Creatine — 92% of 210 reports, versus 84% of 447 for Modafinil.
Creatine has 763 meta-analyses and 2,794 randomized trials on PubMed; Modafinil has 155 and 297.
Based on 1,547 reports about Creatine and 1,097 about Modafinil. Not medical advice.
| Creatine Supplement | Modafinil Medication | |
|---|---|---|
| User score | 52 | 45 |
| Verdict | Mostly positive | Mixed |
| Positive of reports that state an outcome | 69% | 48% |
| Reports | 1,547 | 1,097 |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 763 / 2,794 | 155 / 297 |
| Mainly used for | ||
| Weight loss % reporting improvement | 82% (11) | 100% (5) |
| Appetite % reporting improvement | 67% (3) | 40% (15) |
| Focus % reporting improvement | 92% (210) | 84% (447) |
| Energy % reporting improvement | 97% (205) | 91% (301) |
| Sleep % reporting improvement | 28% (71) | 19% (75) |
| Anxiety % reporting improvement | 68% (22) | 26% (73) |
| Mood % reporting improvement | 85% (103) | 62% (88) |
| Memory % reporting improvement | 91% (70) | 71% (21) |
| Performance % reporting improvement | 97% (316) | 88% (17) |
| Recovery % reporting improvement | 98% (62) | — |
| Pain & inflammation % reporting improvement | 50% (4) | — |
| Digestion % reporting improvement | 0% (6) | — |
| Libido % reporting improvement | 82% (11) | 25% (8) |
| Hormones % reporting improvement | 75% (12) | — |
| Blood sugar % reporting improvement | 100% (3) | — |
| Heart & lipids % reporting improvement | 67% (6) | 9% (11) |
| Skin & hair % reporting improvement | 17% (12) | 50% (2) |
| Longevity % reporting improvement | 100% (4) | — |
| Common side effects | hair loss, stomach issues, insomnia, water retention | insomnia, anxiety, headache, tolerance |
| Typical dose reported | daily | as needed |
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“Creatine - mental and physical performance enhancement”
Our findings represent the most comprehensive available evidence base to inform patients, families, clinicians, guideline developers, and policymakers on the choice of ADHD medications across age groups. Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. New research should be funded urgently to assess long-term effects of these drugs.
Lancet Psychiatry, 2018 ↗“It works well, but you will need to drink lots of water since its a diuretic... getting sucked into a single task is pretty common with me”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate