People mainly take Tmg for mood, energy. Based on 64 first-hand reports and 25 meta-analyses & systematic reviews in the medical literature. Ranked #160 of 1,974 overall.
Of reports that state an outcome, 77% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: This article is a translated summary of the full version of the ARDS Clinical Practice Guideline 2021 published in Japanese (URL: https://www.jrs.or.jp/publication/jrs_guidelines/). The original text, which was written for Japanese healthcare professionals, may include different perspectives from healthcare professionals of other countries.
PubMed 35753956 ↗Conclusion: This review confirms the safety and low donor site morbidity of the TMG flap in normal-weight patients, which is comparable to that of other popular free flaps in breast reconstruction.
PubMed 34091906 ↗Conclusion: Despite ongoing research, uncertainties remain regarding the precise characteristics, transmission routes, and mechanisms of transmitted strains. Comprehensive approaches, including metagenomic sequencing and longitudinal studies, are needed to understand the role of vertical transmission in infant gut microbiome engraftment and its functional implications.
PubMed 40593735 ↗Conclusion: Finally, there has been limited attention given to high-risk groups for waterpipe smoking, such as youth, young adults, pregnant women, and dual or poly tobacco users. These groups would benefit from targeted studies.
PubMed 37286509 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“I take methyl B-12 which should help like TMG”
“With niacin you want to also take TMG and other B vitamins. And never take no flush or extended release niacin”
“Taking it with a methyl donor like TMG at a 1:1 ratio is recommended as all forms of Niacin strip methyl groups”
“TMG will replace the methyl groups the process uses”
“TMG - 500 mg”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate