Across 130 first-hand reports, people mentioned a side effect 8 times (about 6 per 100 reports). The most common: aggression, anger, weird feeling. User reports show what people notice — they can't tell you whether Tmg is safe for you.
“some stuff I take feel weird (TMG/HMB for exemple, I think methyl make me feel to weird and angry).”
“I've tried tyrosine and stimulating adaptogens (panax and rhodiola) and alcar and b-vitamins and TMG but nothing works.”
“when I take ~1g before bed I sleep deep and want to stay in bed longer when it's time to get up”
“after trying it for a week they had absolutely no effect on me”
“Even 250mg gives me sleep issues and irritability/restlessness.”
“TMG (precursor to sam-e aswel) makes me insanely aggressive, yet SAM-E seems to make me more humble and social”
Conclusion: This review confirms the safety and low donor site morbidity of the TMG flap in normal-weight patients, which is comparable to that of other popular free flaps in breast reconstruction.
Conclusion: Finally, there has been limited attention given to high-risk groups for waterpipe smoking, such as youth, young adults, pregnant women, and dual or poly tobacco users. These groups would benefit from targeted studies.