Across 924 first-hand reports, people mentioned a side effect 65 times (about 7 per 100 reports). The most common: suppression, hair loss, acne. User reports show what people notice — they can't tell you whether Testosterone is safe for you.
“my proneness to rage and feelings of "righteous indignancy" (think *"how dare you!"* or anything pertaining to vengeful/personalizing thinking about social slights) have increased.”
“When on T, I noticed there's a time period when you start you may notice mood changes and acne... once leveled out... benefits of more energy, sex drive, and all around well being.”
“testosterone replacement therapy (~12 months)...it made such a difference in other factors in my life - weight loss, libido, etc.”
“TRT changed my life. I was depressed, unmotivated and felt like shit.”
“TRT was the closest I’ve been to death via medicine in my life. Was absolutely terrifying and still feeling effects 4 years later.”
“Mood, energy, mental clarity, libido — everything is rapidly moving into what we consider optimal territory for us.”
Conclusion: Although studies directly comparing the safety of SC vs IM administration of testosterone esters are desirable, clinicians should consider discussing the SC route with their patients because it is easier to self-administer and has the potential to improve patient adherence.
Conclusion: Despite historical beliefs that TTh increases the risk of CV disease, thromboembolic events, BPH, and PCa, recent evidence suggests that TTh conveys less risk than previously perceived. While caution should continue to be exercised, evidence suggests that TTh is a reasonable treatment option in many hypogonadal men who were previously excluded from TTh based on risk factors and prior health histories. Twitchell DK, Pastuszak AW, Khera M. Controversies in Testosterone Therapy. Sex Med Rev 2021;9:149-159.