Nutrients · 2020 · Meta-analysis / systematic review
Passiflora incarnata in Neuropsychiatric Disorders-A Systematic ReviewConclusion: Passiflora incarnata may be helpful in treating some symptoms in neuropsychiatric patients.
PubMed 33352740 ↗Passionflower
People mainly take Passionflower for sleep, anxiety. Based on 75 first-hand reports and 10 meta-analyses & systematic reviews in the medical literature. Ranked #49 of 1,974 overall.
55
User score
Mostly positive31% positive1% mixed19% negative49% unclear
Of reports that state an outcome, 61% are positive.
Clinical research
BModerate research base
10
meta-analyses
8
RCTs
112
papers
What Passionflower does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
BModerate research base
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Nutrients · 2021 · Meta-analysis / systematic review
Herbal Remedies and Their Possible Effect on the GABAergic System and SleepConclusion: Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control. Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.
PubMed 33561990 ↗Pharmacol Res · 2022 · Meta-analysis / systematic review
Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysisConclusion: Medicinal herbs may be promising for the treatment of anxiety. However, these results should be considered preliminary because of the unconvincing sample sizes, together with the potential effectiveness of placebos.
PubMed 35378276 ↗Phytother Res · 2018 · Meta-analysis / systematic review
Herbal medicines in the treatment of psychiatric disorders: 10-year updated reviewConclusion: Although the previous review suggested increasing the adjunctive study of select herbal medicines with pharmaceuticals, this was still only found to sparingly occur in research designs. Aside from this, future focus should involve the incorporation of more biomarker analysis, in particular pharmacogenomics, to determine genetic factors moderating response to herbal medicines.
PubMed 29575228 ↗Phytother Res · 2018 · Meta-analysis / systematic review
Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevancePubMed 29464801 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
800 mgbefore bed
recently/as neededas reported
eveningas reported
before sleepas reported
10gdaily
1000 mgdaily
Reported side effects
How often each side effect came up across all reports.
drowsiness ×2qt prolongation ×1nausea ×1vivid dreams ×1agitation ×1
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“supplements like valerian root, lemon balm, passion flower, and chamomile helpful, as was CES therapy”
“I've recently discovered Passion flower extract and am amazed no one talks about it more. It does need cycling but without fail it causes me to yawn nonstop after I take it.”
“St. John's Wort, Passion Flower, Hops, and Skullcap. My sleep improved with those.”
“Passionflower stacked with a high dose of rosmarinic acid could potentially give a light alcohol sensation without dangerous side effects for the general public. Long QT with passionflower is concerning though.”
“Passionflower extract”
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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate