Inositol vs Niacin for mood
Short answer: For mood, more users report improvement with Inositol — 88% of 60 reports, versus 71% of 21 for Niacin.
Inositol has 209 meta-analyses and 248 randomized trials on PubMed; Niacin has 114 and 379.
Based on 429 reports about Inositol and 269 about Niacin. Not medical advice.
| Inositol Supplement | Niacin Supplement | |
|---|---|---|
| Users say it helped | 67%helped167 reports · high confidence | 71%helped94 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 209 / 248 | 114 / 379 |
| Mainly used for | ||
| Anxiety % reporting improvement | 90% (100) | 93% (14) |
| Mood % reporting improvement | 88% (60) | 71% (21) |
| Sleep % reporting improvement | 100% (43) | 73% (11) |
| Focus % reporting improvement | 79% (14) | 100% (11) |
| Energy % reporting improvement | 67% (3) | 93% (15) |
| Common side effects | stomach issues, diarrhea, brain fog, drowsiness | flushing, flush, stomach issues, liver damage |
| Typical dose reported | 10-25 g | 100-200 mg |
The evidence supporting the use of inositol in the management of PCOS is limited and inconclusive. Clinicians and their patients should consider the uncertainty of the evidence together with individual values and preferences when engaging in shared decision-making regarding the use of inositol for PCOS.
J Clin Endocrinol Metab, 2024 ↗“I personally use Inositol only on nights I may know sleep will be challenging... extra good sleep or perception of such.”
This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
Clin Nutr, 2022 ↗“If you over methylate, niacin may also help you. Binds to free methyl groups... It's how I fixed my heart palpitations after taking methylsulfonymethan.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate