Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
Niacin side effects
Across 269 first-hand reports, people mentioned a side effect 43 times (about 16 per 100 reports). The most common: flushing, flush, stomach issues. User reports show what people notice — they can't tell you whether Niacin is safe for you.
Reported side effects
What got worse for some people
In their own words
“If you over methylate, niacin may also help you. Binds to free methyl groups... It's how I fixed my heart palpitations after taking methylsulfonymethan.”
“Been taking Niacin, but other than the flush, I've found it makes me feel kinda irritable after taking it and my stomach doesn't feel great.”
“it takes close to 10 grams of niacin a day to tame my symptoms and have me feeling good.”
“I've been megadosing Niacin for a couple of years and anecdotally feel like it's improving my health.”
“Had bad flushing w/ the niacin. Felt like I was on fire, massive blotching covered entire body.”
“Ever since I started taking niacin daily it's greatly reduced the frequency and intensity of them, but you have to get the flushing kind.”
Is Niacin safe? What the research covers
Conclusion: In this meta-regression analysis, the use of statin and nonstatin therapies that act via upregulation of LDL receptor expression to reduce LDL-C were associated with similar RRs of major vascular events per change in LDL-C. Lower achieved LDL-C levels were associated with lower rates of major coronary events.
Conclusion: Following a vegan diet may result in deficiencies in micronutrients (vitamin B12, zinc, calcium and selenium) which should not be disregarded. However, low micro- and macronutrient intakes are not always associated with health impairments. Individuals who consume a vegan diet should be aware of the risk of potential dietary deficiencies.