Niacin vs Niacinamide for anxiety
Short answer: For anxiety, more users report improvement with Niacinamide — 100% of 6 reports, versus 93% of 14 for Niacin.
Niacin has 114 meta-analyses and 379 randomized trials on PubMed; Niacinamide has 144 and 72.
Based on 269 reports about Niacin and 56 about Niacinamide. Not medical advice.
| Niacin Supplement | Niacinamide Supplement | |
|---|---|---|
| Users say it helped | 71%helped94 reports · medium confidence | 56%helped20 reports · medium confidence |
| Verdict | Mostly positive | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 114 / 379 | 144 / 72 |
| Mainly used for | ||
| Mood % reporting improvement | 71% (21) | 67% (3) |
| Anxiety % reporting improvement | 93% (14) | 100% (6) |
| Sleep % reporting improvement | 73% (11) | 80% (5) |
| Energy % reporting improvement | 93% (15) | — |
| Heart & lipids % reporting improvement | 85% (13) | — |
| Common side effects | flushing, flush, stomach issues, liver damage | liver damage, depression, flare, flushing |
| Typical dose reported | 100-200 mg | 500 mg / daily |
This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
Clin Nutr, 2022 ↗“If you over methylate, niacin may also help you. Binds to free methyl groups... It's how I fixed my heart palpitations after taking methylsulfonymethan.”
Oral nicotinamide should be considered in healthy patients or organ transplant recipients with history of skin cancer (GRADE: weak recommendation; moderate-quality evidence), in particular of BCC and cSCC.
J Cutan Med Surg, 2022 ↗“In my experience, niacinamide (not niacin) 1000-1500mg a day worked wonders in about 5-7 days.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate