Niacin vs Nicotinamide
Short answer: Overall, Nicotinamide gets more positive reports (100% vs 71%).
Niacin has 114 meta-analyses and 379 randomized trials on PubMed; Nicotinamide has 120 and 239.
Based on 269 reports about Niacin and 17 about Nicotinamide. Not medical advice.
| Niacin Supplement | Nicotinamide Supplement | |
|---|---|---|
| Users say it helped | 71%helped94 reports · medium confidence | 100%helped2 reports · few reports |
| Verdict | Mostly positive | Not enough data |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 114 / 379 | 120 / 239 |
| Mainly used for | ||
| Mood % reporting improvement | 71% (21) | — |
| Energy % reporting improvement | 93% (15) | — |
| Anxiety % reporting improvement | 93% (14) | — |
| Heart & lipids % reporting improvement | 85% (13) | — |
| Focus % reporting improvement | 100% (11) | — |
| Common side effects | flushing, flush, stomach issues, liver damage | None reported |
| Typical dose reported | 100-200 mg | — |
This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
Clin Nutr, 2022 ↗“If you over methylate, niacin may also help you. Binds to free methyl groups... It's how I fixed my heart palpitations after taking methylsulfonymethan.”
NADH supplementation is safe and has a low incidence of side effects. Future investigations are needed to evidence the clinical benefits regarding specific diseases and doses administered.
Am J Physiol Endocrinol Metab, 2024 ↗“I have a shitty demyelinating autoimmune bs going on and i feel so shit i feel all of them. Nicotinamide, nac. Selenium. B1!!! Everything.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate