Glycine vs Inositol for sleep
Short answer: For sleep, more users report improvement with Inositol — 100% of 43 reports, versus 87% of 255 for Glycine.
Glycine has 392 meta-analyses and 620 randomized trials on PubMed; Inositol has 209 and 248.
Based on 695 reports about Glycine and 429 about Inositol. Not medical advice.
| Glycine Supplement | Inositol Supplement | |
|---|---|---|
| Users say it helped | 70%helped299 reports · high confidence | 67%helped167 reports · high confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 392 / 620 | 209 / 248 |
| Mainly used for | ||
| Sleep % reporting improvement | 87% (255) | 100% (43) |
| Anxiety % reporting improvement | 78% (60) | 90% (100) |
| Mood % reporting improvement | 87% (39) | 88% (60) |
| Focus % reporting improvement | 62% (13) | 79% (14) |
| Energy % reporting improvement | 94% (17) | 67% (3) |
| Common side effects | vivid dreams, drowsiness, fatigue, brain fog | stomach issues, diarrhea, brain fog, drowsiness |
| Typical dose reported | 2 g / daily | 10-25 g |
In studies using high-throughput metabolomics, several blood amino acids appear to be consistently associated with the risk of developing type 2 diabetes.
Diabetes Care, 2016 ↗“2 grams with 200mg magnesium before bed gives me crazy good sleep. Crazy vivid dreams.”
The evidence supporting the use of inositol in the management of PCOS is limited and inconclusive. Clinicians and their patients should consider the uncertainty of the evidence together with individual values and preferences when engaging in shared decision-making regarding the use of inositol for PCOS.
J Clin Endocrinol Metab, 2024 ↗“I personally use Inositol only on nights I may know sleep will be challenging... extra good sleep or perception of such.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate