PlainPill
SupplementSkin & hairRecovery

Hyaluronic Acid

People mainly take Hyaluronic Acid for skin & hair, recovery. Based on 46 first-hand reports and 816 meta-analyses & systematic reviews in the medical literature. Ranked #373 of 1,974 overall.

Compare with…Alternatives for skin & hair
31
User score
Mostly positive
22% positive2% mixed0% negative76% unclear

Of reports that state an outcome, 92% are positive.

Clinical research
AStrong research base
816
meta-analyses
1,179
RCTs
34,210
papers

What Hyaluronic Acid does, according to users

Of the people who reported each effect, the share who said it got better.

Skin & hair100% of 12
2 more with fewer than 3 reports
Recovery100% of 2Pain & inflammation100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

BMC Musculoskelet Disord · 2023 · Meta-analysis / systematic review
Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis

Conclusion: The current study found that PRP and PRP + HA were the most successful in improving function and alleviating pain after 3, 6, and 12 months of follow-up. CSC, HA, PRP, and combination therapy did not result in an increase in the incidence of treatment-related side events as compared to placebo.

PubMed 38037038 ↗
Am J Sports Med · 2021 · Meta-analysis / systematic review
Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Conclusion: Patients undergoing treatment for knee OA with PRP can be expected to experience improved clinical outcomes when compared with HA. Additionally, leukocyte-poor PRP may be a superior line of treatment for knee OA over leukocyte-rich PRP, although further studies are needed that directly compare leukocyte content in PRP injections for treatment of knee OA.

PubMed 32302218 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

200 mgnot every day
dailyas reported
125 mgas reported
150 mgas reported
500-1000 mg daily (megadose); 200 mg maintenancedaily
80 mgdaily

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Something I will add is hyaluronic acid.”
Source discussion ↗
“* hyaluronic acid”
Source discussion ↗
“Mega dose of HA?”
Source discussion ↗
“High dose oral hyaluronic acid...probably around 200mg a day but with your issue you might need to keep mega dosing.”
Source discussion ↗
“Topical: Matrixyl 3000, hyaluronic acid”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate