PlainPill

Hyaluronic Acid vs Vitamin C for skin & hair

Short answer: For skin & hair, more users report improvement with Vitamin C — 97% of 29 reports, versus 90% of 20 for Hyaluronic Acid.

Hyaluronic Acid has 816 meta-analyses and 1,179 randomized trials on PubMed; Vitamin C has 738 and 2,072.

Based on 91 reports about Hyaluronic Acid and 928 about Vitamin C. Not medical advice.

Hyaluronic Acid
Supplement
Vitamin C
Supplement
Users say it helped76%helped23 reports · medium confidence64%helped204 reports · high confidence
Verdict
Mostly positive
Mostly positive
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs816 / 1,179738 / 2,072
Mainly used for
Skin & hair
% reporting improvement
90% (20)97% (29)
Immunity
% reporting improvement
—90% (40)
Energy
% reporting improvement
—94% (34)
Mood
% reporting improvement
—88% (25)
Pain & inflammation
% reporting improvement
80% (5)80% (15)
Common side effectsstomach issues, irritationkidney stones, stomach issues, insomnia, bone pain
Typical dose reported200 mg / not every day2000 mg / daily
Hyaluronic Acid
Latest review conclusion

The current study found that PRP and PRP + HA were the most successful in improving function and alleviating pain after 3, 6, and 12 months of follow-up. CSC, HA, PRP, and combination therapy did not result in an increase in the incidence of treatment-related side events as compared to placebo.

BMC Musculoskelet Disord, 2023 ↗
What a user said
“From day 2 of my taking the capsule of hyaluronic acid, my lips stopped peeling. When I stopped taking it, my lips started peeling again.”
Full Hyaluronic Acid profile →
Vitamin C
Latest review conclusion

The failure of vitamin C supplementation to reduce the incidence of colds in the general population indicates that routine vitamin C supplementation is not justified, yet vitamin C may be useful for people exposed to brief periods of severe physical exercise. Regular supplementation trials have shown that vitamin C reduces the duration of colds, but this was not replicated in the few therapeutic trials that have been carried out. Nevertheless, given the consistent effect of vitamin C on the duration and severity of colds in the regular supplementation studies, and the low cost and safety, it m

Cochrane Database Syst Rev, 2013 ↗
What a user said
“I know people say you get enough vitamin C from diet but I feel and look better when I supplement it.”
Full Vitamin C profile →

Related comparisons

Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate