Gelatin

Conclusion: Collagen synthesis rates were elevated with 15 g/day COL but did not have a significant impact on MPS when compared to isonitrogenous higher quality protein sources. Exact mechanisms for these adaptations are unclear, with future research using larger sample sizes, elite athletes, female participants and more precise outcome measures such as muscle biopsies and magnetic imagery.

Conclusion: Crystalloids were less efficient than colloids at stabilizing resuscitation endpoints; guidance on when to switch is urgently required.

Conclusion: Balanced solutions (BS) are the preferred resuscitation fluids for septic shock. High molecular weight hydroxyethyl starch (H-HES) is associated with increased risks of mortality, acute kidney injury (AKI), and renal replacement therapy (RRT), as well as prolonged hospital stays, and its use is advised against. Gelatin is associated with poorer outcomes in terms of mortality, continuous renal replacement therapy (CRRT), and length of hospital stay.

Conclusion: Our network meta-analysis found that balanced crystalloids and albumin decreased mortality more than L-HES and saline in sepsis patients; however, saline or L-HES was better than iso-oncotic albumin or balanced crystalloids in traumatic brain injury patients.