Testosterone vs Tirzepatide for weight loss
Short answer: For weight loss, users rate them about the same: 93% report improvement with Testosterone (45 reports) and 93% with Tirzepatide (195 reports).
Testosterone has 75 meta-analyses and 125 randomized trials on PubMed; Tirzepatide has 214 and 132.
Based on 822 reports about Testosterone and 408 about Tirzepatide. Not medical advice.
| Testosterone Medication | Tirzepatide Medication | |
|---|---|---|
| User score | 54 | 68 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 77% | 76% |
| Reports | 822 | 408 |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 75 / 125 | 214 / 132 |
| Mainly used for | ||
| Weight loss % reporting improvement | 93% (45) | 93% (195) |
| Appetite % reporting improvement | — | 86% (71) |
| Focus % reporting improvement | 82% (28) | 67% (3) |
| Energy % reporting improvement | 92% (76) | 45% (31) |
| Sleep % reporting improvement | 79% (19) | 56% (9) |
| Anxiety % reporting improvement | 80% (25) | — |
| Mood % reporting improvement | 88% (104) | 68% (25) |
| Memory % reporting improvement | 100% (2) | — |
| Performance % reporting improvement | 97% (149) | 83% (12) |
| Recovery % reporting improvement | 91% (23) | — |
| Pain & inflammation % reporting improvement | 67% (6) | 86% (7) |
| Digestion % reporting improvement | — | 20% (5) |
| Libido % reporting improvement | 93% (70) | 33% (6) |
| Hormones % reporting improvement | 90% (91) | 50% (2) |
| Blood sugar % reporting improvement | — | 80% (10) |
| Heart & lipids % reporting improvement | 62% (8) | 88% (8) |
| Skin & hair % reporting improvement | 40% (5) | 0% (2) |
| Longevity % reporting improvement | 50% (2) | — |
| Common side effects | suppression, hair loss, acne, water retention | fatigue, nausea, constipation, stomach issues |
| Typical dose reported | 200 mg / weekly | 7.5 mg |
The guidelines also provide recommendations regarding identification of patients, dosing, monitoring, and follow-up. This Practice Pearl will discuss evidence-based testosterone therapy for management of HSDD in postmenopausal women.
Menopause, 2023 ↗“Feel the best I've ever felt in my life. TRT and peptides have been game changers for me!”
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“Tirzepatide works so well! Do some research in the r/peptides subreddit and the r/tirzepatide subreddit. It's the most effective thing I've ever seen for appetite suppressant.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate