Creatine vs Tadalafil for performance
Short answer: For performance, users rate them about the same: 97% report improvement with Creatine (320 reports) and 97% with Tadalafil (61 reports).
Creatine has 763 meta-analyses and 2,794 randomized trials on PubMed; Tadalafil has 120 and 347.
Based on 1,564 reports about Creatine and 214 about Tadalafil. Not medical advice.
| Creatine Supplement | Tadalafil Medication | |
|---|---|---|
| User score | 53 | 65 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 67% | 78% |
| Reports | 1,564 | 214 |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 763 / 2,794 | 120 / 347 |
| Mainly used for | ||
| Weight loss % reporting improvement | 82% (11) | — |
| Appetite % reporting improvement | 67% (3) | — |
| Focus % reporting improvement | 92% (211) | 88% (8) |
| Energy % reporting improvement | 97% (205) | 100% (6) |
| Sleep % reporting improvement | 27% (73) | 100% (4) |
| Anxiety % reporting improvement | 62% (24) | 75% (4) |
| Mood % reporting improvement | 85% (103) | 100% (9) |
| Memory % reporting improvement | 91% (70) | — |
| Performance % reporting improvement | 97% (320) | 97% (61) |
| Recovery % reporting improvement | 98% (62) | 100% (6) |
| Pain & inflammation % reporting improvement | 50% (4) | 100% (2) |
| Digestion % reporting improvement | 0% (6) | — |
| Libido % reporting improvement | 82% (11) | 91% (82) |
| Hormones % reporting improvement | 75% (12) | 100% (3) |
| Blood sugar % reporting improvement | 100% (3) | 100% (2) |
| Heart & lipids % reporting improvement | 67% (6) | 100% (17) |
| Skin & hair % reporting improvement | 17% (12) | — |
| Longevity % reporting improvement | 100% (4) | 100% (2) |
| Common side effects | hair loss, stomach issues, insomnia, water retention | headache, stuffy nose, heartburn, lower back |
| Typical dose reported | daily | 2.5-5 mg / daily or 5-10 mg every other day |
The results of the meta-analysis suggest that creatine supplementation did not significantly alter serum creatinine levels (standardized mean difference = 0.48, 95% confidence interval 0.24-0.73, P = .001, I2 = 22%), and did not alter plasma urea values (standardized mean difference = 1.10, 95% confidence interval 0.34-1.85, P = .004, I2 = 28%). The findings indicate that creatine supplementation does not induce renal damage in the studied amounts and durations.
J Ren Nutr, 2019 ↗“I actually feel a lot better. Mentally clearer and more balanced, like I have my brain back.”
Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients' sexual confidence. Furthermore, patients and their partners prefer tadalafil to sildenafil. Hence, tadalafil may be a better choice for ED treatment.
Int Urol Nephrol, 2017 ↗“After a week of 2.5 mg twice a day, this is my favourite drug ever. My brain fog has gone...My mood is so much better, similar to an SSRI but without the flat feeling.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate