PlainPill

Ashwagandha vs Kanna for mood

Short answer: For mood, more users report improvement with Kanna — 94% of 84 reports, versus 53% of 446 for Ashwagandha.

Ashwagandha has 48 meta-analyses and 59 randomized trials on PubMed; Kanna has 8 and 0.

Based on 2,447 reports about Ashwagandha and 231 about Kanna. Not medical advice.

Ashwagandha
Supplement
Kanna
Supplement
Users say it helped44%helped1,321 reports · high confidence77%helped102 reports · high confidence
Verdict
Mixed
Mostly positive
ResearchAResearch: StrongBResearch: Moderate
Meta-analyses / RCTs48 / 598 / 0
Mainly used for
Anxiety
% reporting improvement
88% (881)88% (42)
Mood
% reporting improvement
53% (446)94% (84)
Sleep
% reporting improvement
77% (233)100% (2)
Energy
% reporting improvement
53% (125)92% (13)
Libido
% reporting improvement
62% (127)100% (8)
Common side effectsanhedonia, drowsiness, fatigue, depressiondrowsiness, appetite suppression, brain fog, agitation
Typical dose reported800-1600 mg / after dinner300mg sublingual
Ashwagandha
Latest review conclusion

The current systematic review and dose-response meta-analysis of RCTs revealed a beneficial effect in both stress and anxiety following Ashwagandha supplementation. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.

Phytother Res, 2022 ↗
What a user said
“I paired it with maca and ashwaganda and it legit felt like a steroid cycle.”
Full Ashwagandha profile →
Kanna
Latest review conclusion

Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.

Nat Genet, 2024 ↗
What a user said
“Kanna tablets. Dissolve under the tongue...I can't sing Kannas praises enough. It's the instant cure for my brain fog, lack of energy, and lack of motivation.”
Full Kanna profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate