GW-501516 vs Tirzepatide for weight loss
Short answer: For weight loss, more users report improvement with Tirzepatide — 93% of 195 reports, versus 86% of 50 for GW-501516.
GW-501516 has 0 meta-analyses and 0 randomized trials on PubMed; Tirzepatide has 214 and 132.
Based on 307 reports about GW-501516 and 405 about Tirzepatide. Not medical advice.
| GW-501516 Substance | Tirzepatide Medication | |
|---|---|---|
| User score | 46 | 68 |
| Verdict | Mostly positive | Mostly positive |
| Positive of reports that state an outcome | 64% | 76% |
| Reports | 307 | 405 |
| Research | DResearch: None | AResearch: Strong |
| Meta-analyses / RCTs | 0 / 0 | 214 / 132 |
| Mainly used for | ||
| Weight loss % reporting improvement | 86% (50) | 93% (195) |
| Appetite % reporting improvement | 50% (4) | 86% (71) |
| Focus % reporting improvement | — | 67% (3) |
| Energy % reporting improvement | 95% (19) | 47% (30) |
| Sleep % reporting improvement | 0% (2) | 56% (9) |
| Mood % reporting improvement | 100% (2) | 68% (25) |
| Performance % reporting improvement | 93% (71) | 83% (12) |
| Recovery % reporting improvement | 100% (3) | — |
| Pain & inflammation % reporting improvement | — | 86% (7) |
| Digestion % reporting improvement | — | 20% (5) |
| Libido % reporting improvement | — | 33% (6) |
| Hormones % reporting improvement | — | 50% (2) |
| Blood sugar % reporting improvement | — | 80% (10) |
| Heart & lipids % reporting improvement | 89% (19) | 88% (8) |
| Skin & hair % reporting improvement | — | 0% (2) |
| Longevity % reporting improvement | 50% (2) | — |
| Common side effects | cancer risk, acne, fatigue, brain fog | fatigue, nausea, constipation, stomach issues |
| Typical dose reported | 20 mg | 7.5 mg |
TirzepatideFull Tirzepatide profile →
Latest review conclusion
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗What a user said
“mounjaro has been the best. I lost like 15 pounds in two months on this thing.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate