PlainPill

Enclomiphene vs Hcg for hormones

Short answer: For hormones, more users report improvement with Enclomiphene — 90% of 137 reports, versus 85% of 41 for Hcg.

Enclomiphene has 2 meta-analyses and 3 randomized trials on PubMed; Hcg has 324 and 972.

Based on 545 reports about Enclomiphene and 190 about Hcg. Not medical advice.

Enclomiphene
Medication
Hcg
Medication
Users say it helped59%helped185 reports · high confidence64%helped53 reports · medium confidence
Verdict
Mixed
Mostly positive
ResearchBResearch: ModerateAResearch: Strong
Meta-analyses / RCTs2 / 3324 / 972
Mainly used for
Hormones
% reporting improvement
90% (137)85% (41)
Libido
% reporting improvement
70% (30)93% (14)
Mood
% reporting improvement
64% (22)100% (3)
Energy
% reporting improvement
77% (13)100% (3)
Performance
% reporting improvement
40% (5)—
Common side effectseye floaters, vision issues, mood swings, hair losssuppression, high estrogen, leg seizures, acne
Typical dose reportedNot listedNot listed
Enclomiphene
Latest review conclusion

SERM therapy is associated with significantly improved levels of TT, LH, and FSH in hypogonadal men compared to placebo, and significantly enhanced levels of LH and FSH compared to T gel. The findings suggest that SERM therapy effectively increases TT levels in men with functional hypogonadism and should be considered as an alternative to T gel therapy.

Arch Endocrinol Metab, 2025 ↗
What a user said
“I second Enclomiphene citrate. Been on 12.5mg per day sublingual pill and my test went from 430 to 950. No side effects other than being more horny.”
Full Enclomiphene profile →
Hcg
Latest review conclusion

In people with type 2 diabetes, the cardiovascular and kidney benefits of GLP-1 receptor agonists are consistent regardless of SGLT2 inhibitor use.

Circulation, 2024 ↗
What a user said
“hcg.. although it may raise estrogen too much. worked great for me, strength increases, amazing libido, lost some fat.”
Full Hcg profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate