What people actually say
5,470 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
P21Mostly positive
“I'm recovering from TBI...I've been taking semax, P21, fish oil, curcumin, ALCAR, ALA, Lions Mane, noopept, alpha GPC...I'm making good progress.”Source discussion ↗
P21Mostly positive
“after injecting 2mg SID for a week something is happening... P21 seems to significantly enhance my memory and linguistic abilities while incorporating a subtle, gradual mood lift”Source discussion ↗
P21Mostly positive
“It doesn't directly increase motivation, but I do notice when taking it that my inner monologue is a lot less forgiving with procrastination”Source discussion ↗
P21Mostly positive
“my stack is SEMAX, P21, fish oil, curcumin, black seed oil, ALCAR, ALA, alpha GPC, and lions mane”Source discussion ↗
P21Mostly positive
“I have insulfated what appeared to be in th 2mg-7mg range. ... I did notice an almost instantaneous brightening of sensory awareness”Source discussion ↗
P21Mostly positive
“I am super enjoying P21. Jus feels like my brain fog is gone and everything is running how it should.”Source discussion ↗
FisetinMixed
“I've been taking high dose (20mg-kg/day/4days/month) fisetin supplements for about 5 months now. A few days ago I noticed that my hair was getting darker again.”Source discussion ↗
FisetinMixed
“I overdosed on Fisetin in January of this year and am getting side effects up to now. I had 60 capsules in one sitting and I also had 10 ultra strength ones(so equivallent of 18g).”Source discussion ↗
FisetinMixed
“I'm 28 and take courses of fisetin at 20 mg/kg/day x 2 days to prevent senescent cell accumulation. I've had no side effects.”Source discussion ↗
FisetinMixed
“Concentration was the most notable. But what is unique to fisetin is a compete elimination of my impulsiveness. Like i feel very stable and even-keeled weeks after that 6 day regimen.”Source discussion ↗
FisetinMixed
“I've been taking fisetin with galactomannan for about a year prior to this and noticed an improvement in my thought and energy levels”Source discussion ↗
FisetinMixed
“I noticed my sleep has been really deep but also coupled with intense intense dreams... Only negative so far is some loose stools that are much darker than normal... Overall feeling pretty tired”Source discussion ↗
FisetinMixed
“I have noticed a really nice increase in clarity of thought when I take it daily”Source discussion ↗
FisetinMixed
“Try CAAKG or Fisetin, works great for me.”Source discussion ↗
FisetinMixed
“one of the best things I have done for my skin has been the Mayo protocol using Fisetin as a senolytic. Within a couple weeks of taking it, my skin was glowing.”Source discussion ↗
FisetinMixed
“That included compounds such as: Niacin, NMN, Apigenin, Quercetin, Fisetin...my liver tests came back to normal after 8 weeks.”Source discussion ↗
FisetinMixed
“I found it gave me a noticeable lift after my first round of 20 mg/kg/day for 2 days, which is the Mayo Clinic protocol for senolytic effects”Source discussion ↗
FisetinMixed
“Also fisetin! I need to improve my longevity stack”Source discussion ↗
ClonidineMostly positive
“Clonidine really helped me when I was getting off benzos. I still use it now as a replacement for when I get anxiety.”Source discussion ↗
ClonidineMostly positive
“it made me feel dizzy, sleepy, cognitively much worse during the day...felt like the two medications were fighting for supremacy.”Source discussion ↗
ClonidineMostly positive
“For acute anxiety or panic attacks I take Clonidine at 100mcg. It also makes an excellent sleeping pill.”Source discussion ↗
ClonidineMostly positive
“I get some sleep now with .1mg clonidine and 25 mg atarax combined but it's often short and really broken up.”Source discussion ↗
ClonidineMostly positive
“Clonidine does as well. I wonder if this is where its efficacy in anxiety disorders comes from.”Source discussion ↗
ClonidineMostly positive
“I noticed that clonidine did indeed reduce BPM and overall 'fight or flight' responses but didn't help with ADHD.”Source discussion ↗
ClonidineMostly positive
“Ask your doctor to try you on 0.1 mg clonidine half twice daily and whole at night. That helped my vyvanse heart and anxiety issues greatly”Source discussion ↗
ClonidineMostly positive
“I have clonidine prescribed at .2mg but even that doesn’t help a ton.”Source discussion ↗
ClonidineMostly positive
“Clonidine was the worst, though. The anticholinergic affects were way too intense for me. It aggravated my symptoms.”Source discussion ↗
ClonidineMostly positive
“Once I got on clonidine, and it calmed my nervous system down, it started eating gluten again and I have no issue what so ever with it.”Source discussion ↗
ClonidineMostly positive
“My doctors have tried me out on clonidine and strattera, but neither of these were effective for me.”Source discussion ↗
ClonidineMostly positive
“My psychiatrist tried prescribing me clonidine to help and it didn’t work.”Source discussion ↗
ClonidineMostly positive
“I have comfort meds clonidine and hydroxzyine but they’re too damn sedating to take during the day.”Source discussion ↗
ClonidineMostly positive
“I can never fall asleep without taking something strong, like Ambien or clonidine, which makes me super tired and drowsy in the morning.”Source discussion ↗
ClonidineMostly positive
“clonidine is the only thing I've found that has been able to stop that, rather than just sedate me”Source discussion ↗
ClonidineMostly positive
“I once tried clonidine and it made me so unbelievably depressed. BE CAREFUL if you try this medicine, as it can induce depression”Source discussion ↗
Adderall XrMixed
“the stuff works for me real well with My prescribed Adderall XR.”Source discussion ↗
Adderall XrMixed
“After rehab I got a prescription for 30 milligrams of Adderall XR and I couldn't feel it at all.”Source discussion ↗
Adderall XrMixed
“The difference has been night and day. It's far superior to any generic IR version I tried, and I've been much more productive over the past month.”Source discussion ↗
Adderall XrMixed
“I love feeling focused and calm throughout my day, however the side-effects are too much.”Source discussion ↗
Adderall XrMixed
“it absolutely makes me more productive but i feel less like myself so if i can achieve that productivity in other ways i'd like to.”Source discussion ↗
Adderall XrMixed
“I had startlingly great results for several years with Adderall XR 20mg with no negatives whatsoever. ... Tolerance gradually built up...”Source discussion ↗