PlainPill

What people actually say

5,470 first-hand quotes, shortened but never edited — each links to the original discussion.

AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
Resistance TrainingMostly positive
“Now I do 3 lifting days (upper, lower, full-body split). Big change here was actually lifting to failure.”
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Resistance TrainingMostly positive
“I've been able to lift higher weights than when I started (20% on average)”
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Resistance TrainingMostly positive
“I focused on strength and muscle (re)gain with 3 - 4 times a week full body weight lifting, and 2 - 3 times 60 minute zone 2 incline WALKING.”
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Resistance TrainingMostly positive
“Resistance training and sex are the only ones off hand that I can remember for certain.”
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Resistance TrainingMostly positive
“I've built lots of muscle - definitely no body builder but I'm happy with the amount of lean muscle I've been able to build”
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Resistance TrainingMostly positive
“Still working out at least 4 days a week and hitting my 10k steps everyday”
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Resistance TrainingMostly positive
“I train at the gym three times per week, mostly focusing on compound movements with moderate weights.”
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Resistance TrainingMostly positive
“I started going to the gym 5-7 days a week”
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DihexaMostly positive
“The effects have been promising, because I found myself not only better in actual routine work, but also studying and learning, which was really hard to me before. It felt like combining mental clarity with neural plasticity.”
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DihexaMostly positive
“I've taken it three times, all orally. It's easily the most profound substance i've tried yet...Better memory and general retention, greater plasticity...improved physical performance”
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DihexaMostly positive
“fish oil psilocybin dihexa and fast for at least 24 hrs once per week... these are the things i feel were absolutely critical in my recovery.”
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DihexaMostly positive
“some peptides like dihexa, Cerebrolysin, selank, semax, and Retatrutide also helped my recovery”
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DihexaMostly positive
“still testing it I haven't taken as much but nothing life changing... slightly improved mood along with focus”
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DihexaMostly positive
“took Dyhexa and no meds to sleep, and I slept like a truck, very heavy”
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DihexaMostly positive
“I’ve used both Dihexa and P21... Dihexa increases BDNF to ridiculous levels, but my subjective experience felt quite mixed — the benefits only lasted while on the substance”
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DihexaMostly positive
“The most of my creativity comes from increased BDNF. So, good halucinogens (do not recommend) or semax/noopept/dihexa/whate'va.”
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DihexaMostly positive
“Bar none, and by a huge margin, the most effective and risky nootropic I have tried.”
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DihexaMostly positive
“Dihexa and inhaled BPC-157/TB-500 for past brain trauma/concussions. I've trialed a lot of peptides and these are the ones I found that had the most impact.”
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DihexaMostly positive
“40mg Dihexa once weekly (to help repair any cannabis related brain damage) | First of all, cannabis does not cause brain damage. Secondly, I would strongly advise people to not use dihexa until more studies have been done on it.”
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DihexaMostly positive
“Dihexa made me remenber stuff that i have done in my childhood”
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DihexaMostly positive
“I have an Einstein Stack...highly experimental...Want to run mice studies before trying it.”
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DihexaMostly positive
“I took a total of 500mg of dihexa from august 6th to mid September...I'm legitimately very intelligent now.”
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DihexaMostly positive
“Semax and dihexa certainly assist short term in my experience.”
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“I really got better from anxiety ... on effexor. My personal miracle drug does not work for everyone.”
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“I tried Venlafaxine and my ADHD improved significantly. However, it also had a certain amount of excitotoxicity, and I couldn't sleep at night.”
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“I started Venlafaxine three months ago when I got depressed again...and it got me out of bed, but NAC was the game changer for me.”
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“I found that Venlafaxine was good once it down regulated my norephineprine. Before I was constantly full of somatic anxiety but now it’s definitely improved.”
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“When I quit Effexor many years ago, I had to slowly decrease the dose over a period that was twice as long as I had been on them. Brain zaps from hell.”
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“never actually found anything that helped. Not one thing... Supplements I've tried include fish oil pills, htp-5, fluoxetine, effexor, adderall, ritalin, vitamin b complexes, and st johns wort.”
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“I've been taking Effexor which has shown to be effective for some people. It has helped me some but it's not 100% gone.”
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“venlafaxine did something...This at least helps me sleep...it just gives me that flattened serotonin effect where everything is 'fine,' apathy, emotional blunting, low libido.”
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“after the second week I could only sleep 2 hours a night and I felt anxious and foggy all day.”
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“i had Effexor prescribed. It did not seem to help but was prone to crying fits on it and felt like crap.”
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“The withdrawal symptoms, including extreme anxiety, are absolutely hell and I recommend staying away from it.”
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“Be careful with Effexor. If you have to take it, and it really helped, go for it. I spent literally two years tapering off of it the withdrawals were that severe.”
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“effexor does fucking suck. It helped me at the time but after taking it for only a year I now have chronic fatigue”
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“I have been on effexor 150mg for 1 year now which helps almost cured the depression and helped me regain mental clarity”
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“I tried Venlafaxine and my ADHD improved significantly. However, it also had a certain amount of excitotoxicity, and I couldn't sleep at night”
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“i was on effexor which was marvelous until the libido side effects creeped in”
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SSRIMostly negative
“then i came to SSRI , it helped a little bit then.”
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