What people actually say
5,470 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
ClonazepamMixed
“I took Klonopin, 1mg at night for almost 5 years. It was the only drug to help me sleep”Source discussion ↗
L-DopaMixed
“I find 4-hydroxyphenylalanine and L-γ-glutamylethylamide make a huge difference in keeping myself on an even keel..”Source discussion ↗
L-DopaMixed
“L-Dopa is making me a bit anxious but sure helps me with depression and focus.”Source discussion ↗
L-DopaMixed
“I have been taking L-Dopa and it has been working for me. My moods have been consistent and my anxiety have been almost non-existent.”Source discussion ↗
L-DopaMixed
“I've taken both L-Dopa and 5-HTP before and they didn't do shit.”Source discussion ↗
L-DopaMixed
“I have previously tried combining it with l-dopa, but the nightmare that is trying to take a reasonable dose of l-dopa without peripheral-dopamine related side effects is another, very long story.”Source discussion ↗
L-DopaMixed
“I load dopamine with L-DOPA+. and Baicalein (MAO-B inhibition)+liposomal ECGC (COMT inhibition). The combo was life changing I uptook so much dopamine also using NAC and ALCAR to speed intracellular uptake. I still feel that 300mg L-DOPA load 3 months later”Source discussion ↗
L-DopaMixed
“I would discourage the use of L-DOPA, it's long term effects can be quite deleterious to your goals; chronic administration tends to result in irreversible and substantial side-effects”Source discussion ↗
L-DopaMixed
“Within 60 minutes, I wanted to rip my wifes panties off... My ADHD is completely gone... I was afraid to take it again this morning.”Source discussion ↗
L-DopaMixed
“I wouldn't mess around with L-Dopa unless you know what you are doing. Just asking for trouble with that one, IMO.”Source discussion ↗
L-DopaMixed
“I'm getting tyrosine, Alpha GPC, even l dopa. Doesn't do anything until some dopamine release happens.”Source discussion ↗
L-DopaMixed
“I've taken 5-HTP, L-Dopa, L-Theanine, and L-Tyrosine. None of them have done anything for me over a span of weeks”Source discussion ↗
L-DopaMixed
“I took P5P, zinc, L-dipa, tyrosine and ext supplements you guys recommended”Source discussion ↗
L-DopaMixed
“ive tried 98% l-dopa and hated it, crashed hard after 40 minutes to 1h”Source discussion ↗
L-DopaMixed
“I would be particularly careful with both the Mucuna pruriens, L-DOPA, and Rhodiola”Source discussion ↗
L-DopaMixed
“I don't think L-Dopa is going to help you at all.”Source discussion ↗
L-DopaMixed
“I took some L-Dopa and triggered a nasty reaction”Source discussion ↗
SarcosineMostly positive
“sarcosine + NAC nailed it. I literally cannot tell the difference. I feel so amazing.”Source discussion ↗
SarcosineMostly positive
“long courses of Sarcosine (daily for a month+ at a time) helped tremendously and permanently, however when I tried it again more recently it triggered anxiety and overthinking.”Source discussion ↗
SarcosineMostly positive
“GlyT1 Inhibitors: Sarcosine and (lesser extent) dimethylglycine cause glycine reuptake inhibition, proven quite effective for anxiety ... Helps me a lot.”Source discussion ↗
SarcosineMostly positive
“2000mg sarcosine helps with the emotional blunting often seen in schizophrenia, and it aids cognitive performance through enhanced NMDA signaling. I have taken both for a few weeks and they have helped me tremendously.”Source discussion ↗
SarcosineMostly positive
“500mg sarcosine mid day every other day and I'm getting so much better.”Source discussion ↗
SarcosineMostly positive
“Sarcosine has been the only supplement that made significant changes when it came to depression and parts of my anxiety.”Source discussion ↗
SarcosineMostly positive
“One thing I add to NAC dose (2g or so) is also 2g of Sarcosine (methyl-glycine). This was in a supplement called profrontal. Can add in alpha Lipoic acid as an enhancer. This helps me a ton with anhedonia!”Source discussion ↗
SarcosineMostly positive
“just 1 dose of sarcosine had me feeling incredible. It felt as though I could breathe again. Anxiety lifted, mood was relaxed but NOT tired”Source discussion ↗
SarcosineMostly positive
“Nothings worked except Sarcosine which has helped me very subtly.”Source discussion ↗
SarcosineMostly positive
“I've had considerable result with this stack, though, a bit inconsistent.”Source discussion ↗
SarcosineMostly positive
“Sarcosine has been phenomenal for my social anxiety lately.”Source discussion ↗
SarcosineMostly positive
“I combine it with N-Acetyl-Cystine and helps me with mood and anhedonia. I'm not sure about it's effects on sleep quality.”Source discussion ↗
SarcosineMostly positive
“I got those symptoms after taking shit tons of it for a while... I think sarcosine and glycine help me reverse it... I remember being super anhedonic... Now I'm back to feeling caffeine pretty much as normal again. Sarcosine and glycine seemed to give me that energy and emotion back.”Source discussion ↗
SarcosineMostly positive
“Sarcosine, a schizophrenic supplement treatment, has successfully treated my Dissociative Identity Disorder and about a whopping 43-68% of my crippling DPDR/dissociation/brain fog; am taking 500mg twice a day.”Source discussion ↗
SarcosineMostly positive
“I've only been on Sarcosine (1 gram three times a day) for almost a week now, but it seems to have completely obliterated my old, self-destructively negative thinking patterns”Source discussion ↗
SarcosineMostly positive
“I've since made the switch to ND's lemon balm tablets/sarcosine as well as gingko, 5-htp... been positive”Source discussion ↗
Resistance TrainingMostly positive
“more weight training. I was pumping iron, but not often enough so I lost more muscle mass than what I needed to.”Source discussion ↗
Resistance TrainingMostly positive
“I find resistance training especially effective. Quads, glutei, calves, triceps, biceps, shoulders, abs - get them all reasonable sore, and you crash like a baby.”Source discussion ↗
Resistance TrainingMostly positive
“Last year I stopped wasting my time with videos games and started hitting the weights. Changed my life.”Source discussion ↗
Resistance TrainingMostly positive
“I made incredible strides and even worked through the right shoulder issue that had been hampering me for years.”Source discussion ↗
Resistance TrainingMostly positive
“my hack to get it up without pharmaceuticals and have increased libido. Is doing lots of squats with weights”Source discussion ↗
Resistance TrainingMostly positive
“Around month 2 I also started resistance training because I know it's especially important with PMOS...I've just slowly increased my dose whenever I felt like it was needed”Source discussion ↗
Resistance TrainingMostly positive
“Brilliant focus in the gym too - for me having a decent routine at the gym also helps with my mood and adhd”Source discussion ↗