What people actually say
85 first-hand quotes, shortened but never edited — each links to the original discussion.
AllWeight lossAppetiteFocusEnergySleepAnxietyMoodMemoryPerformanceRecoveryPain & inflammationDigestionLibidoHormonesBlood sugarHeart & lipidsSkin & hairImmunityLongevity
BerberineMixed
“I also use Berberine to keep insulin low but it doesn't do a lot of the other stuff metformin does”Source discussion ↗
BerberineMixed
“I for now use berberine”Source discussion ↗
BerberineMixed
“I don't think berberine decreases testosterone?”Source discussion ↗
BerberineMixed
“I'm taking Berberine myself because I suspect the effects might be similar.”Source discussion ↗
BerberineMixed
“Berberine activates AMPK, like Metformin does”Source discussion ↗
SemaglutideMostly positive
“I've been inconstent with all 3, and I haven't seen much weight loss.”Source discussion ↗
SemaglutideMostly positive
“the only anti-aging drug I take is rapamycin and semaglutide, both of which blow metformin out of the water.”Source discussion ↗
SemaglutideMostly positive
“Semaglutide!... Not a supplement but Semaglutide and Tirzapetide are showing great promise in this area.”Source discussion ↗
SemaglutideMostly positive
“My wife has Sema,selenk, Semax”Source discussion ↗
SemaglutideMostly positive
“I started on semaglutide for 2 months very little weight loss like 10@15 loss”Source discussion ↗
MOTS-CMixed
“Any low blood sugar with mot or tesa?”Source discussion ↗
MOTS-CMixed
“SS-31 and Mots C seemed to help with fatigue in the meantime.”Source discussion ↗
MOTS-CMixed
“MOTS-C and AICAR for mitochondrial health/AMPK activation”Source discussion ↗
MOTS-CMixed
“I tried MOTS-C 1mg/day and that didn't do anything for me.”Source discussion ↗
MOTS-CMixed
“2nd week of 1mg MOTS mon-fri and i feel like i can dig pretty deep during workouts despite having a lot of fatigue. i suspect it could be a placebo but will pay attention to how i feel after this vial. no noticeable diff”Source discussion ↗
MetforminMixed
“metformin, rapamycin, caloric restriction, etc.”Source discussion ↗
MetforminMixed
“Metformin tends to give some pretty nasty diarrhea when you first start it, and with some people it doesn't go away”Source discussion ↗
MetforminMixed
“My ex used to take it (PCOS). It fucked her stomach up pretty badly so she stopped after a while.”Source discussion ↗
MetforminMixed
“Metformin”Source discussion ↗
MetforminMixed
“I ended up getting metformin by other means. Been on it for a year and a half now. My A1C and my fasting glucose has dropped dramatically”Source discussion ↗
FastingMostly positive
“Do quarterly fasting for 24 hours to help remove any cells that might be damaged”Source discussion ↗
FastingMostly positive
“The biggest factor I have found is fasting”Source discussion ↗
FastingMostly positive
“Fasting is amazing for recovery.”Source discussion ↗
FastingMostly positive
“Fasting is ironically great for building mass... A >3 day fast will boost your natural HGH”Source discussion ↗
FastingMostly positive
“eating better and fasting most of the day also quitting drinking helped a ton”Source discussion ↗
Keto DietMostly positive
“tried keto?”Source discussion ↗
Keto DietMostly positive
“lower carb diet, ketoish diet”Source discussion ↗
Keto DietMostly positive
“I gave the keto diet about 7 weeks and it just wasnt for me.”Source discussion ↗
Keto DietMostly positive
“my results are pretty crazy because i also did hop on a keto diet as well... i ended up dropping from 223lbs to 183 pounds in just 5 months which is very realistic with the help of peptides ofcourse.”Source discussion ↗
Keto DietMostly positive
“I jumped on the keto diet and lost 30lbs in 30 days. I was miserable and extremely angry!”Source discussion ↗
Alpha Lipoic AcidMixed
“Grape Seed Extract, NAC, Alpha Lipoic Acid”Source discussion ↗
Alpha Lipoic AcidMixed
“Nutricost Alpha lipoic acid - 600mg per day, to enhance creatine absorption in muscle tissues”Source discussion ↗
Alpha Lipoic AcidMixed
“High dose phosphatylcholine, alpha lipoic acid and glutathione for detoxing the brain.”Source discussion ↗
Alpha Lipoic AcidMixed
“**Alpha-lipoic acid**: a powerful antioxidant great for long-term brain health”Source discussion ↗
Alpha Lipoic AcidMixed
“Not an expert, but what came to mind we're: ALA NAC NAD Berberine Melatonin L-tyrosine”Source discussion ↗
Apple Cider VinegarMostly positive
“Supplements That Reduce Blood Sugar Spikes: Cinnamon, Berberine, & Apple Cider Vinegar”Source discussion ↗
Apple Cider VinegarMostly positive
“including bitter melon or apple cider vinegar”Source discussion ↗
Apple Cider VinegarMostly positive
“Should take the HCL with ACV or it will end up not in your stomach but in your intestine.”Source discussion ↗
Apple Cider VinegarMostly positive
“sometimes I feel like I may be ingesting too much probiotics via ACV, plus the occasional Kombucha”Source discussion ↗
Apple Cider VinegarMostly positive
“Apple Cider Vinegar”Source discussion ↗