MOTS-C
People mainly take MOTS-C for energy, performance, weight loss. Based on 129 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #106 of 1,974 overall.
Of reports that state an outcome, 53% are positive.
What MOTS-C does, according to users
Of the people who reported each effect, the share who said it got better.
4 more with fewer than 3 reports
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
1–4 randomized controlled trials, no meta-analysis yet. The grade measures how much human research exists — read the conclusions below for what it found.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“Any low blood sugar with mot or tesa?”
“SS-31 and Mots C seemed to help with fatigue in the meantime.”
“MOTS-C and AICAR for mitochondrial health/AMPK activation”
“I tried MOTS-C 1mg/day and that didn't do anything for me.”
“2nd week of 1mg MOTS mon-fri and i feel like i can dig pretty deep during workouts despite having a lot of fatigue. i suspect it could be a placebo but will pay attention to how i feel after this vial. no noticeable diff”
Other options for energy
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate