PlainPill
Medication

Zofran

The short answer. There isn't much data on Zofran yet — 4 mentions, 2 with a clear outcome — so treat these numbers as anecdotal. There is a moderate body of research — 1 meta-analyses and 20 trials.

Compare with…
What users report
50%helped2 reports · few reports
1 helped0 mixed1 didn't help

From 4 mentions in total — the rest didn't say how it went and aren't counted.

Clinical research
BModerate research base
1
meta-analyses
20
RCTs
95
papers

What Zofran does, according to users

Of the people who reported each effect, the share who said it got better.

No specific effects reported yet.
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Front Pharmacol · 2023 · Meta-analysis / systematic review
The preventive effects of ondansetron on chemotherapy-induced nausea and vomiting in adult cancer patients: systematic review from ClinicalTrials.gov

Conclusion: The collective findings from these trials showed an effective management of CINV using ondansetron. Conclusion: Through a comprehensive overview of clinical trials, the use of ondansetron in adult cancer patients represents a significant improvement in CINV management.

PubMed 38074143 ↗

Dosage people report

We don't list doses for prescription medications. Dosing should only come from a doctor or pharmacist.

Reported side effects

How often each side effect came up across all reports.

birth defects ×1

What users say

First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.

“Happy I took zofran prior or I'd definitely been puking”
HelpedRead the discussion ↗
Top discussions (4)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate