Across 428 first-hand reports, people mentioned a side effect 64 times (about 15 per 100 reports). The most common: nausea, fatigue, anhedonia. User reports show what people notice — they can't tell you whether Tirzepatide is safe for you.
“I’m currently on tirzepatide 7.5mg (midway dose). Stacking sema because tirz isn’t helping it’s serious insomnia and sexual side effects.”
“I lost 75 lbs on Tirzepatide. Unfortunately I didn’t know enough about peptides and about muscle loss! I’m paying for it now.”
“I lost allover 12.5 kg, which is about 0.9 kg per week... The appetite suppression was very noticeable, and I had hardly any side effects other than diarrhea and very brief stomach cramps.”
“Since starting GLP-1 drugs three months ago (tirzepatide) I have experienced what feel to me like low dopamine symptoms (brain fog, lowered desire, motivation, anhedonia)”
“I've been microdosing tirzepatide (glp-1) for some other inflammatory health conditions and it helps immensely with some pain I have had. However, I have a mild case of anhedonia because of it.”
“I've been taking Tirzepatide 2,5mg for 4 weeks - no side effects at all. I noticed a reduced hunger and I ate overall less food.”
Conclusion: Our data show that s.c. tirzepatide had a more pronounced effect on HbA1c and weight reduction compared with s.c. semaglutide in people with type 2 diabetes. Both drugs, particularly higher doses of tirzepatide, increased gastrointestinal adverse events.