Conclusion: This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Does Tirzepatide help with weight loss?
Yes, for most people. 94% of 206 people who reported on Tirzepatide for weight loss say it improved. 4% noticed no change and 2% say it got worse. That is about the typical result for weight loss (91% across 22 options).
Weight loss: what users report
94%better206 reports · high confidence
193 better9 no change4 worse
Ranked #2 of 22 for weight loss.
What people say about Tirzepatide and weight loss
“mounjaro has been the best. I lost like 15 pounds in two months on this thing.”
“I lost 75 lbs on Tirzepatide. Unfortunately I didn’t know enough about peptides and about muscle loss! I’m paying for it now.”
“I lost 33 in 4 weeks, 59 in 11 weeks on Tirzep + Test + Deca + Tesa while putting on muscle.”
“I lost allover 12.5 kg, which is about 0.9 kg per week... The appetite suppression was very noticeable, and I had hardly any side effects other than diarrhea and very brief stomach cramps.”
What the research says
AResearch: Strong214 meta-analyses · 132 trials on PubMed
Pharmacol Res · 2021
Anti-diabetic drugs and weight loss in patients with type 2 diabetesDiabetologia · 2024
Subcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trialsConclusion: Our data show that s.c. tirzepatide had a more pronounced effect on HbA1c and weight reduction compared with s.c. semaglutide in people with type 2 diabetes. Both drugs, particularly higher doses of tirzepatide, increased gastrointestinal adverse events.
Metabolism · 2025
Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysisConclusion: Potent GLP-1 RAs, such as tirzepatide and semaglutide, demonstrate greater overall weight loss but are associated with a significant reduction in lean mass.
Side effects people mention
nausea 17fatigue 16anhedonia 8constipation 8stomach issues 8
What else is Tirzepatide used for?
Information only — not medical advice. How we count