Tirzepatide reviews: what real users say
We read 428 first-hand mentions of Tirzepatide from health and supplement communities. 287 of them say clearly how it went — and 75% of those say it helped.
Where people say it works: weight loss (94% of 206), appetite (84% of 79), mood (63% of 27), performance (83% of 12).
Where it disappoints: energy (only 44% of 32 say better), libido (only 33% of 6 say better), digestion (only 20% of 5 say better).
Most common complaints: nausea, fatigue, anhedonia, constipation, stomach issues. All side effects →
Positive experiences
“Tirzepatide works so well! Do some research in the r/peptides subreddit and the r/tirzepatide subreddit. It's the most effective thing I've ever seen for appetite suppressant.”
“mounjaro has been the best. I lost like 15 pounds in two months on this thing.”
“Tirz quite literally helped me quit nicotine and it has helped many quit alcohol.”
“I ended up going the “gray” market route for Tirzepatide and did notice a night and day difference.”
“I lost 33 in 4 weeks, 59 in 11 weeks on Tirzep + Test + Deca + Tesa while putting on muscle.”
“I lost allover 12.5 kg, which is about 0.9 kg per week... The appetite suppression was very noticeable, and I had hardly any side effects other than diarrhea and very brief stomach cramps.”
Negative and mixed experiences
“I’m currently on tirzepatide 7.5mg (midway dose). Stacking sema because tirz isn’t helping it’s serious insomnia and sexual side effects.”
“The Tirz was amazing and I dropped to a maintenance dose after I hit 195. When I stopped all peptides for two weeks prior to surgery, the Tirz didnt do anything when I restarted.”
“I lost 75 lbs on Tirzepatide. Unfortunately I didn’t know enough about peptides and about muscle loss! I’m paying for it now.”
“Since starting GLP-1 drugs three months ago (tirzepatide) I have experienced what feel to me like low dopamine symptoms (brain fog, lowered desire, motivation, anhedonia)”
“I've been microdosing tirzepatide (glp-1) for some other inflammatory health conditions and it helps immensely with some pain I have had. However, I have a mild case of anhedonia because of it.”
“Tirz tanked my energy, and there for my lifts. Lost amazing weight on it though.”
Quotes are verbatim and link to the original public discussion. Information only — not medical advice. How we collect reports