People mainly take Glycine for sleep, anxiety, mood. Based on 367 first-hand reports and 392 meta-analyses & systematic reviews in the medical literature. Ranked #47 of 1,974 overall.
Of reports that state an outcome, 73% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: In studies using high-throughput metabolomics, several blood amino acids appear to be consistently associated with the risk of developing type 2 diabetes.
PubMed 27208380 ↗Conclusion: Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with sustainable dietary patterns and guidelines. This study was registered in PROSPERO as CRD42023439239.
PubMed 39433088 ↗Conclusion: However, our results should be interpreted with caution owing to the small sample size. More trials should be conducted in the future to validate our findings.
PubMed 40718787 ↗Conclusion: Several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk.
PubMed 35349649 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Glycine (for when I'm out of bone broth)”
“Fermented foods, fish oil and glycine can help with it.”
“Glycine helped the most, a couple of grams a day.”
“3. Glycine”
“I've started it recently and has done a lot for my chronic fatigue. 3 g before bed does the trick. Massively helped my sleep quality”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate