PlainPill

Glycine vs Lysine for skin & hair

Short answer: For skin & hair, users rate them about the same: 100% report improvement with Glycine (12 reports) and 100% with Lysine (3 reports).

Glycine has 392 meta-analyses and 620 randomized trials on PubMed; Lysine has 180 and 469.

Based on 695 reports about Glycine and 41 about Lysine. Not medical advice.

Glycine
Supplement
Lysine
Supplement
Users say it helped70%helped299 reports · high confidence80%helped10 reports · few reports
Verdict
Mostly positive
Mostly positive
ResearchAResearch: StrongAResearch: Strong
Meta-analyses / RCTs392 / 620180 / 469
Mainly used for
Sleep
% reporting improvement
87% (255)—
Anxiety
% reporting improvement
78% (60)100% (2)
Mood
% reporting improvement
87% (39)100% (2)
Energy
% reporting improvement
94% (17)50% (2)
Skin & hair
% reporting improvement
100% (12)100% (3)
Common side effectsvivid dreams, drowsiness, fatigue, brain fogdrowsiness
Typical dose reported2 g / daily2400mg / daily
Glycine
Latest review conclusion

In studies using high-throughput metabolomics, several blood amino acids appear to be consistently associated with the risk of developing type 2 diabetes.

Diabetes Care, 2016 ↗
What a user said
“2 grams with 200mg magnesium before bed gives me crazy good sleep. Crazy vivid dreams.”
Full Glycine profile →
Lysine
Latest review conclusion

We estimate that developmental disorders caused by DNMs have an average prevalence of 1 in 213 to 1 in 448 births, depending on parental age. Given current global demographics, this equates to almost 400,000 children born per year.

Nature, 2017 ↗
What a user said
“L-lysine has worked wonders for me. It only helps if I start taking it right when I feel that slight tingling sensation... I take 2 1000mg tablets 3 times a day for 2-3 days.”
Full Lysine profile →

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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate