PlainPill
SupplementEnergyFocusMood

COQ10

People mainly take COQ10 for energy, focus, mood. Based on 226 first-hand reports and 176 meta-analyses & systematic reviews in the medical literature. Ranked #229 of 1,974 overall.

Compare with…Alternatives for energy
40
User score
Mostly positive
21% positive5% mixed4% negative69% unclear

Of reports that state an outcome, 70% are positive.

Clinical research
AStrong research base
176
meta-analyses
405
RCTs
7,233
papers

What COQ10 does, according to users

Of the people who reported each effect, the share who said it got better.

Energy97% of 39Focus88% of 8Mood100% of 7Performance100% of 5Skin & hair67% of 3Longevity33% of 3
7 more with fewer than 3 reports
Recovery100% of 2Heart & lipids100% of 2Hormones50% of 2Libido100% of 1Memory100% of 1Anxiety100% of 1Sleep100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Ann Med · 2024 · Meta-analysis / systematic review
Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis

Conclusion: These findings suggested that CoQ10 pretreatment is an effective intervention in improving IVF/ICSI outcomes for women with DOR. Still, this meta-analysis included relatively limited sample sizes with poor descriptions of their methodologies. Rigorously conducted trials are needed in the future.

PubMed 39129455 ↗
Clin Nutr · 2022 · Meta-analysis / systematic review
ESPEN micronutrient guideline

Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.

PubMed 35365361 ↗
Nutr Neurosci · 2023 · Meta-analysis / systematic review
Nutrition and bipolar disorder: a systematic review

Conclusion: Taken together, these preliminary findings suggest that dietetic approaches might be included as part of BD treatment. Also considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.

PubMed 35608150 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

dailyas reported
200 mgas reported
100 mgmorning and evening
100 mgas reported
ubiquinol 400 mgdaily
200 mcgas reported

Reported side effects

How often each side effect came up across all reports.

aggression ×1insomnia ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“Try ubiquinol which is the reduced form of COQ10 AKA ubiquinone. Ubiquinol is more bioavailable.”
Source discussion ↗
“Q10”
Source discussion ↗
“Just ordered some CoQ10 w/ PQQ to try.”
Source discussion ↗
“CoQ10 combo: ubiquinol 400 mg, PQQ 20 mg, ALA 50 mg, turmeric 50 mg”
Source discussion ↗
“If you are taking metformin Co-Q10 is a must IMO but it has to be a strong dose in the oxidized form.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate