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Choline side effects

Across 608 first-hand reports, people mentioned a side effect 52 times (about 9 per 100 reports). The most common: depression, headache, fatigue. User reports show what people notice — they can't tell you whether Choline is safe for you.

Reported side effects

depression26
headache9
fatigue4
anxiety4
drowsiness4
vivid dreams2
anhedonia2
acne1

What got worse for some people

In their own words

“I swear to God, the amount of focus, mental clarity, attention, and energy is insane. Only choline.”
MixedRead the discussion ↗
“Thus, the addition of choline seemed to have no effect on my experience.”
Didn't helpRead the discussion ↗
“I never take choline I've found it makes all the racetams give me anxiety.”
Didn't helpRead the discussion ↗
“more simple supplements like omega 3, multivitamins, creatine (for working out) and choline. None have helped with my mental consistency as of yet.”
Didn't helpRead the discussion ↗
“I had been taking piracetam and choline but didn't feel anything at all from it.”
Didn't helpRead the discussion ↗

Is Choline safe? What the research covers

AResearch: Strong280 meta-analyses · 460 randomized trials on PubMed
Clin Nutr · 2022
ESPEN micronutrient guideline

Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.

Choline side effects: what 608 users report — PlainPill